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Improving Outcomes in Psychosis Associated With Substance Use Using Aripiprazole

2014-08-27 03:12:29 | BioPortfolio

Summary

This project focuses on the under-researched group of individuals who develop psychotic episodes of short duration (less than four weeks) while using substances. This includes individuals diagnosed with psychotic disorder not otherwise specified (PNOS) or substance-induced psychotic disorder (SIP) AND substance abuse or dependence. Very little is known about the most appropriate maintenance/relapse prevention management of these subjects. These individuals are not diagnosed with a primary psychosis because psychotic symptoms are too short-lived or non-specific, the onset of substance use precedes the onset of psychotic symptoms and the subject has not experienced sufficient psychotic symptoms in the absence of substance use. However, previous studies have shown that they are at high risk of recurrence of psychotic symptoms. Thus, this project will assess the efficacy of the second-generation antipsychotic aripiprazole for maintenance treatment of subjects who had a recent psychotic episode of short duration associated with substance use. The investigators will compare aripiprazole and placebo for preventing the recurrence of psychotic symptoms and decreasing substance use during a 6-month maintenance phase.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Substance Abuse

Intervention

Behavioral Intervention

Location

The Zucker Hillside Hospital
Glen Oaks
New York
United States
11004

Status

Not yet recruiting

Source

Feinstein Institute for Medical Research

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:29-0400

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Medical and Biotech [MESH] Definitions

Abuse, overuse, or misuse of a substance by its injection into a vein.

Abuse, overuse, or misuse of a substance by ingestion.

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