Antibiotic Prophylaxis for Simple Hand Lacerations

2014-08-27 03:12:30 | BioPortfolio


Research Question: In emergency department patients with simple hand cuts, do prophylactic antibiotics reduce the risk of wound infections?


Simple hand lacerations, defined as hand lacerations that do not involve special structures such as bones, tendons, vessels, or nerves, are common in the emergency departments. The exact rate of infection in such wounds is unclear. It is also not clear whether prescribing prophylactic antibiotics reduces the risk of infection in simple hand lacerations. The objective of this randomized double blind controlled study is to: 1. Identify the rate of infection in simple hand lacerations, 2. Identify factors or wound characteristics that increase the risk of infection, and 3. Assess whether prescribing prophylactic antibiotics decreases the risk of infections in such wounds compared to placebo.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Simple Hand Lacerations


cephalexin, clindamycin, placebo


State University of New York, Downstate Medical Center
New York
United States




State University of New York - Downstate Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:30-0400

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Medical and Biotech [MESH] Definitions

A congenital anomaly of the hand or foot, marked by the webbing between adjacent fingers or toes. Syndactylies are classified as complete or incomplete by the degree of joining. Syndactylies can also be simple or complex. Simple syndactyly indicates joining of only skin or soft tissue; complex syndactyly marks joining of bony elements.

An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.

Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.

Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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