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Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

2014-07-23 21:08:35 | BioPortfolio

Summary

Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Crossover Assignment, Primary Purpose: Basic Science

Conditions

Pancreatitis

Intervention

Creon, No enzyme therapy

Location

Centre de Recherche sur Volontaires
Bobigny
France
93000

Status

Completed

Source

Institut National de la Recherche Agronomique

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:35-0400

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Medical and Biotech [MESH] Definitions

INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

C-type lectins that restrict growth of bacteria in the intestinal epithelia and have bactericidal activity against gram-positive and gram-negative bacteria. They also regulate proliferation and differentiation of KERATINOCYTES following injury. Human pancreatitis-associated protein-1 (Reg3a) is overexpressed by pancreatic ACINAR CELLS in patients with CHRONIC PANCREATITIS. It is also highly expressed by pancreatic, bladder, and gastrointestinal cancer cells and may serve as a diagnostic biomarker.

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