Track topics on Twitter Track topics that are important to you
This is a single-site, prospective cohort study of diabetic participants undergoing Roux-en-Y gastric bypass (RYGB) at the Hospital of the University of Pennsylvania. After a screening visit to determine eligibility, participants will be studied at baseline (up to 3 weeks prior to surgery) and after surgery on postoperative days 10 +/- 3 and 90 +/- 14. We will measure the GLP-1 response following ingestion of a test meal prior to and after RYGB. Other factors that also affect glucose homeostasis will also be measured, including insulin and glucagon.
Many diabetic patients who have Roux-en-Y gastric bypass (RYGB) have rapid improvements in their blood sugars within days of their surgery, even before they have lost much weight. Changes in levels of hormones released by the small intestine as a consequence of gastric bypass may be an important factor in the rapid improvement of glycemia. One of these hormones, glucagon-like peptide-1 (GLP-1), has an important effect on insulin secretion from the pancreas and may account for the dramatic improvements in blood sugars. This study seeks to identify whether GLP-1 levels within the first 1 to 2 weeks after surgery predict whether diabetes will improve or resolve after surgery. In order to meet inclusion criteria, participants must have type 2 diabetes for less than 10 years and be scheduled to undergo gastric bypass at HUP. Hormone levels will be measured during three study visits. The first visit will occur about 2 to 3 weeks before surgery, followed by two postoperative visits (1 to 2 weeks and 3 months after surgery). Hormone levels will be measured after study participants drink about ¾ of a cup of Boost Plus over 60 minutes.
Allocation: Non-Randomized, Control: Active Control, Intervention Model: Single Group Assignment, Masking: Open Label
Mixed meal challenge
Clinical Translational Research Center
Not yet recruiting
University of Pennsylvania
Published on BioPortfolio: 2014-07-23T21:08:38-0400
Insulin resistance (or pre-diabetes) is diagnosed using the oral glucose tolerance test. However, high blood glucose levels during this test may adversely impact on microvascular function....
In a randomized, cross-over designed study, the investigators examined the effectiveness of the carbohydrate counting method after consumption of mixed meals typical of the Greek cuisine w...
The aim of the current study was to compare the effects of three ready-to-eat mixed meals, with a high fiber content and low glycemic index, on postprandial glycemic and insulinemic respon...
study hypothesis to examine the acute effects on glycaemia and islet hormone secretion of increased levels of endogenous GLP-1 and GIP on islet cell function in men with type 2 diabetes. T...
MIDAS involves an assessment of glucose levels obtained before and after bariatric surgery. There are two different procedural tests involved; an oral glucose tolerance test (mixed meal) a...
To determine the influence of meal composition on the glycaemic impact of different carbohydrate staples, and the accuracy of "adjusted calculated meal GI" compared with "measured mixed-meal GI".
Obesity is prevalent and related to poor outcomes in Type 2 diabetes. Evening preference and late meal times have been shown to be associated with obesity, but data are lacking in people with Type 2 d...
This study assessed the safety and performance of the Omnipod personalized model predictive control (MPC) algorithm using an investigational device in adults with type 1 diabetes in response to overes...
The timing of exercise relative to meal consumption has recently been identified as potentially moderating the effectiveness of exercise on glycemic responses in type 2 diabetes mellitus (T2DM). The a...
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.
Excessive thirst manifested by excessive fluid intake. It is characteristic of many diseases such as DIABETES MELLITUS; DIABETES INSIPIDUS; and NEPHROGENIC DIABETES INSIPIDUS. The condition may be psychogenic in origin.
Diabetes is a lifelong condition that causes a person's blood sugar level to become too high. The two main types of diabetes are: type 1 diabetes type 2 diabetes In the UK, diabetes affects approximately 2.9 million people. There are a...