Advertisement

Topics

Paracetamol Metabolism in Post Operative Conditions

2014-08-27 03:12:36 | BioPortfolio

Summary

Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)

Description

D-15 to D0: selection

- patient information and non-opposition obtained

- inclusion and non inclusion criteria check

- clinical exam

D-1 to D0 : 24 hours diuresis

D0 : operation day

Before anesthesia :

- urine collection (paracetamol metabolites dosage)

- blood sampling (glutathion and liver function test)

Surgery:

- 1st paracetamol intake before closing

- Then administration every 6 hours

D1 to D4 :

- 24 hours urine collection (metabolites dosage)

- blood sampling et D1 and D4(glutathion and liver function test)

D5 : final clinical exam

Study Design

Time Perspective: Cross-Sectional

Conditions

Aortic Surgery and Treatment Post Operative With Paracetamol During 4 Days

Location

CHU Clermont-Ferrand
Clermont-Ferrand
France
63003

Status

Completed

Source

University Hospital, Clermont-Ferrand

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:36-0400

Clinical Trials [2782 Associated Clinical Trials listed on BioPortfolio]

A PhaseⅡ/ Ⅲ Seamless Study to Evaluate Efficacy and Safety of Paracetamol Injection as Adjuvant to Morphine-based Postoperative Analgesia

Paracetamol,a classical analgesic agent,constitutes an essential component of multi-modal analgesia. This medication is generally safe, well tolerated and effective within recommended dail...

Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy

GlaxoSmithKline will be conducting this trial to compare analgesic efficacy of paracetamol 1000 mg vs 650 mg. The post-surgical dental pain model will be used to evaluate the analgesic ef...

Effect of Parecoxib on Post-Craniotomy Pain

Aim of this trial: To investigate whether post-craniotomy analgesia with (i) intravenous (IV) parecoxib plus intravenous paracetamol is superior to (ii) intravenous paracetamol alone. ...

Conventional Versus Mini-Sternotomy for Aortic Valve Surgery

Minimally-invasive operative techniques have been introduced in cardiac surgery. These techniques may have several advantages such as a decrease in post operative pain, lower morbidity an...

Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroidectomy

The scientific interest of this study is to improve post-operative comfort in patients after thyroid surgery using simple, inexpensive techniques. The investigator expects that local appli...

PubMed Articles [30182 Associated PubMed Articles listed on BioPortfolio]

Post-operative outcomes in older patients: a single-centre observational study.

Improved life-expectancies have seen increased rates of older patients undergoing surgery worldwide. These patients are at increased risk of post-operative complications. Australian evidence is limite...

Surgical Treatment Of Synchronous Type B Acute Aortic Dissection And Abdominal Aortic Aneurysm.

We report the results of the operative treatment of synchronous type B acute aortic dissection (TBAAD) and infrarenal abdominal aortic aneurysm (AAA).

High Annual Hospital Volume is Associated with Decreased in Hospital Mortality and Complication Rates Following Treatment of Abdominal Aortic Aneurysms: Secondary Data Analysis of the Nationwide German DRG Statistics from 2005 to 2013.

The aim of this study was to analyse the association between annual hospital procedural volume and post-operative outcomes following repair of abdominal aortic aneurysms (AAA) in Germany.

Cost-Effectiveness of Colchicine treatment on Post-Operative Atrial fibrillation (POAF) events in patients of major cardiac surgery.

Post-operative atrial fibrillation (POAF) occurs in 20-50% of patients amid post-operative stay after Cardiac Surgery. We intend to determine whether colchicine therapy in patients undergoing cardiac ...

THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatme...

Medical and Biotech [MESH] Definitions

Surgical treatment for severe AORTIC VALVE STENOSIS. Transcatheter aortic valve replacement (TAVR) is used as an alternative option in patients who are deemed at high risk or inoperable for traditional open-heart surgery.

A specialty in which manual or operative procedures are used in the treatment of disease, injuries, or deformities.

Intraoperative computer-assisted 3D navigation and guidance system generally used in neurosurgery for tracking surgical tools and localize them with respect to the patient's 3D anatomy. The pre-operative diagnostic scan is used as a reference and is transferred onto the operative field during surgery.

Small clusters of chemoreceptive and supporting cells located near the ARCH OF THE AORTA; the PULMONARY ARTERIES; and the coronary arteries. The aortic bodies sense PH; CARBON DIOXIDE; and oxygen concentrations in the BLOOD and participate in the control of RESPIRATION. The aortic bodies should not be confused with the PARA-AORTIC BODIES in the abdomen (which are sometimes also called aortic bodies).

Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.

More From BioPortfolio on "Paracetamol Metabolism in Post Operative Conditions"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Urology
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...


Searches Linking to this Trial