Paracetamol Metabolism in Post Operative Conditions

2014-08-27 03:12:36 | BioPortfolio


Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)


D-15 to D0: selection

- patient information and non-opposition obtained

- inclusion and non inclusion criteria check

- clinical exam

D-1 to D0 : 24 hours diuresis

D0 : operation day

Before anesthesia :

- urine collection (paracetamol metabolites dosage)

- blood sampling (glutathion and liver function test)


- 1st paracetamol intake before closing

- Then administration every 6 hours

D1 to D4 :

- 24 hours urine collection (metabolites dosage)

- blood sampling et D1 and D4(glutathion and liver function test)

D5 : final clinical exam

Study Design

Time Perspective: Cross-Sectional


Aortic Surgery and Treatment Post Operative With Paracetamol During 4 Days


CHU Clermont-Ferrand




University Hospital, Clermont-Ferrand

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:36-0400

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