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Determination of the Amount of Propofol Needed to Supplement 5% Sevoflurane for Intubation of Children Without Neuromuscular Blockade

2014-08-27 03:12:38 | BioPortfolio

Summary

The purpose of this study is to determine the least amount of propofol that is needed to place a breathing tube in children 1-12 years old.

Description

The practice of tracheal intubation of children without neuromuscular blockade (TIWNB) is widespread in pediatric anesthesia practices. There are several different methods reported for TIWNB, most of which involve administration of an inhaled anesthetic in combination with another medication. The technique of administering propofol IV, immediately after IV placement, after a sevoflurane induction is a popular methods for pediatric TIWNB in the United States and worldwide (personal communication, and personal practice of this technique). To date, nobody has studied this technique, and therefore nobody has quantified the amount of propofol needed in this context.

The practice of tracheal intubation of children without neuromuscular blockade (TIWNB) is widespread in pediatric anesthesia practices. There are several different methods reported for TIWNB, most of which involve administration of an inhaled anesthetic in combination with another medication. The technique of administering propofol IV, immediately after IV placement, after a sevoflurane induction is a popular methods for pediatric TIWNB in the United States and worldwide (personal communication, and personal practice of this technique). To date, nobody has studied this technique, and therefore nobody has quantified the amount of propofol needed in this context.

Study Design

Allocation: Non-Randomized, Control: Dose Comparison, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Conditions

Intubation

Intervention

propofol

Location

University of Virginia Health System
Charlottesville
Virginia
United States
22911

Status

Completed

Source

University of Virginia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:38-0400

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Medical and Biotech [MESH] Definitions

An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.

Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.

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