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Chlamydia Trachomatis Immunology and Vaccinology Study

2014-07-23 21:08:41 | BioPortfolio

Summary

The primary objective is to prospectively follow 200 women with or at risk of cervicitis to determine the chlamydia-specific cellular responses that correlate with protection against incident infection. The hypothesis is that a positive IFN-y response by peripheral CD4+ T cells responding to stimulation with HSP60 will be significantly associated with protection from incident C. trachomatis infection.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Chlamydia

Location

Magee-Womens Hospital of UPMC
Pittsburgh
Pennsylvania
United States
15213

Status

Not yet recruiting

Source

University of Pittsburgh

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:41-0400

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Antigen-Specific Cell Mediated Immune Response to Chlamydia Trachomatis

This is an exploratory study in which the investigators will develop a way to identify the cell responses most strongly associated with protection against chlamydia infection. This study ...

Transmission of Genital and Extra-genital Chlamydia Trachomatis Infections in Women

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Sexually transmitted Chlamydia trachomatis infections are a widespread public health concern due to their prevalence and potentially devastating reproductive consequences, including pelvic...

Check it: A New Approach to Controlling Chlamydia Transmission in Young People

This study, named "Check it," is a bundled program for African American (AA) men ages 15-24 that includes community testing for chlamydia and gonorrhea, expedited treatment for subjects wh...

Treatment Failure of Chlamydial Infection in Females in Youth Correctional Facilities

Chlamydia is a common infection among youth and can be given from one person to another during sex. Many people who have chlamydia have no signs of infection at all, but can pass the infec...

PubMed Articles [119 Associated PubMed Articles listed on BioPortfolio]

Perspective: My 37 Year Journey Through Chlamydia Research: Chlamydia Antigen Analysis Using Monoclonal Antibodies and Major Histocompatibility Complex Molecules.

Chlamydia antigen analysis enables understanding of disease pathogenesis, facilitates development of diagnostic immunoassays and is essential to the design of a subunit Chlamydia trachomatis vaccine. ...

What Is the Optimal Time to Retest Patients With a Urogenital Chlamydia Infection? A Randomized Controlled Trial.

Chlamydia trachomatis is a common, often recurring sexually transmitted infection, with serious adverse outcomes in women. Current guidelines recommend retesting after a chlamydia infection, but the o...

Can Chlamydia Serology Be Used to Help Inform a Potential Future Chlamydia Vaccination Strategy?

Is screening for chlamydia and gonorrhea in men who have sex with men associated with reduction of the prevalence of these infections? A systematic review of observational studies.

Neisseria gonorrhoeae (gonorrhea) could become untreatable in the near future. Indeed, while the treatment of symptomatic gonorrhea in core groups, such men who have sex with men (MSM), is crucial for...

The emerging role of ASC in dendritic cell metabolism during Chlamydia infection.

Chlamydia trachomatis is a bacterial agent that causes sexually transmitted infections worldwide. The regulatory functions of dendritic cells (DCs) play a major role in protective immunity against Chl...

Medical and Biotech [MESH] Definitions

Species of CHLAMYDIA causing pneumonitis in mice and hamsters. These isolates formerly belonged to CHLAMYDIA TRACHOMATIS.

A genus of the family CHLAMYDIACEAE whose species cause a variety of diseases in vertebrates including humans, mice, and swine. Chlamydia species are gram-negative and produce glycogen. The type species is CHLAMYDIA TRACHOMATIS.

Type species of CHLAMYDIA causing a variety of ocular and urogenital diseases.

Infections with bacteria of the genus CHLAMYDIA.

A chronic infection of the CONJUNCTIVA and CORNEA caused by CHLAMYDIA TRACHOMATIS.

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