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The main focus of the study is :
- To estimate seroprevalence of AI in poultry-exposed and non-exposed human populations.
- To estimate the incidence of AI in poultry-exposed and non-exposed human populations.
- To investigate risk factors associated with AI infections in occupationally-exposed poultry workers.
The secondary objectives of the study :
- To investigate patterns in transmission of AI to household contacts of AI clinical cases
- To isolate AI viruses from acute cases
- To monitor the pathogenicity and disease severity of AI viruses causing human infections
This 4-year prospective cohort study to compare individuals with occupational exposure to poultry with non-poultry exposed adult controls for evidence of incident and previous infections with AI viruses.At the start of this study, study staff will obtain informed consent,and a blood sample will be obtained from study volunteers to establish baseline levels of antibodies against avian influenza types H4-H12.Subjects will be interviewed regarding their exposures, medical history,and behaviors using a close-ended questionnaire specifically tailored for this study.After one year, study subjects will be interviewed again to note any changes in exposure variables.At this time, another blood sample will be obtained and tested for any changes in antibodies' levels. The same procedures will be repeated at the final visit after another year.Exposed individuals will be selected from rural areas where poultry is commonly raised. Non-exposed controls will be selected from urban neighborhoods in Cairo.
Observational Model: Cohort, Time Perspective: Prospective
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Published on BioPortfolio: 2014-08-27T03:12:42-0400
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