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Studies of Avian Influenza Transmission to Humans in Egypt

2014-08-27 03:12:42 | BioPortfolio

Summary

The main focus of the study is :

- To estimate seroprevalence of AI in poultry-exposed and non-exposed human populations.

- To estimate the incidence of AI in poultry-exposed and non-exposed human populations.

- To investigate risk factors associated with AI infections in occupationally-exposed poultry workers.

The secondary objectives of the study :

- To investigate patterns in transmission of AI to household contacts of AI clinical cases

- To isolate AI viruses from acute cases

- To monitor the pathogenicity and disease severity of AI viruses causing human infections

Description

This 4-year prospective cohort study to compare individuals with occupational exposure to poultry with non-poultry exposed adult controls for evidence of incident and previous infections with AI viruses.At the start of this study, study staff will obtain informed consent,and a blood sample will be obtained from study volunteers to establish baseline levels of antibodies against avian influenza types H4-H12.Subjects will be interviewed regarding their exposures, medical history,and behaviors using a close-ended questionnaire specifically tailored for this study.After one year, study subjects will be interviewed again to note any changes in exposure variables.At this time, another blood sample will be obtained and tested for any changes in antibodies' levels. The same procedures will be repeated at the final visit after another year.Exposed individuals will be selected from rural areas where poultry is commonly raised. Non-exposed controls will be selected from urban neighborhoods in Cairo.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Avian Influenza

Location

St. Jude Children's Research Hospital
Memphis
Tennessee
United States
38105

Status

Recruiting

Source

St. Jude Children's Research Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:42-0400

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Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.

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