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The proposed study will test efficacy of HMB in free acid gel to decrease muscle damage, improve muscle strength, and diminish the inflammatory response following an acute exercise stress. HMB in a free acid gel or in CaHMB capsule form will be administered as either a single dose before a bout of acute exercise or in multiple doses (one before and three daily doses for the 3 days following the acute exercise). We hypothesize that HMB in free acid gel will result in less muscle damage, diminished inflammatory response, and improved muscle strength recovery than either a placebo or CaHMB treatment following a bout of acute eccentric exercise. Our endpoints will include measurements of: (1) markers for muscle damage (CPK and LDH); (2) muscle strength and soreness; (3) indicators of inflammation (CRP, TNF-α, IL-6, IL-1ra and IL-18).
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
CaHMB, HMB Free Acid Gel, Placebo
Iowa State University
Not yet recruiting
Metabolic Technologies Inc.
Published on BioPortfolio: 2014-07-23T21:08:41-0400
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