Evaluating Modes of Influenza Transmission Between Humans

2014-08-27 03:12:42 | BioPortfolio


Most countries of the world, including the USA are making preparations for a possible influenza pandemic. Such an event will constitute a global public health emergency, but it is impossible to predict when this will happen. Up to 80 million people could die worldwide, so as much as possible needs to be done in advance to find ways of how the impact can be reduced. Although the investigators know that medical interventions such as anti-influenza drugs and antibiotics will be important, even in well resourced countries these might be in short supply. Vaccines will also be important but these will not be available until at least 4-5 months after the pandemic has started. This means that other non-pharmaceutical measures could well be important such as social distancing, school closures and the use of face masks. Guidance also needs to be developed so that families can care for each other whilst minimizing the spread of infection. To do these things, the investigators need to know how influenza is transmitted from person-to person. This is poorly understood at present. The investigators also need to know if face masks work before recommendations for public use can be made. The best way to study influenza transmission and the effectiveness of masks is to perform a study using healthy adult volunteers. The investigators will do this by giving some volunteers normal influenza via nasal drops. When they get symptoms the investigators will create an 'experimental household' by getting them to live with other non-infected volunteers for 48 hours, in a specially designed quarantine isolation unit. Some of the non-infected volunteers will be unprotected; others will be selected randomly to wear either face masks or a special plastic 'cloak' so that they do not touch their faces; another group will wear both. The investigators will then measure the rate at which the different groups get 'flu'. From these data the investigators can work out whether it is touching the face or coughing and sneezing that spreads flu most or whether both are important; the investigators can also deduce how well face masks work to prevent spread. The investigators need almost 2000 volunteers for this study, it will take at least 2 years to complete and it will be very costly, however, the results will be of global importance. If the study is successful, the investigators can tell governments around the world whether face masks work to prevent influenza and be clearer about the guidance that should be given to families.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention




No face touch, Surgical face mask, Surgical face mask + no face touch


Retroscreen Virology Ltd
United Kingdom




University of Nottingham

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:42-0400

Clinical Trials [4118 Associated Clinical Trials listed on BioPortfolio]

Assessment of the Effectivity of Total-Face Mask for Noninvasive Ventilation During Acute Respiratory Failure

Total-face mask may improve the efficacy of NIV compared to conventional face mask in patients with acute respiratory failure due to enhanced tolerance and the allowance of higher airway p...

Evaluation of a Full Face Mask and Headgear for the Treatment of Obstructive Sleep Apnea

Currently Fisher & Paykel Healthcare (FPH) is developing a new full face mask. The objective of this clinical investigation is to evaluate the usability and acceptance of the investigative...

CO2 Clearance During Noninvasive Ventilation (NIV)

In this randomized cross over study the investigators will evaluate the effects on gas exchange and patients' tolerance of a new CO2 non rebreathing devices incorporated in the mask vs the...

Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation

The purpose of this study is to compare the use of a laryngeal mask airway (LMA) vs. face-mask ventilation (FMV) during first-line neonatal resuscitation in Mulago Hospital, Kampala, Ugand...

Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure

The purpose of this study is to compare the Total Face Mask™ (Respironics, Inc., Pittsburgh, PA) (covering whole face) and the standard oronasal facemask (covering nose and mouth) for th...

PubMed Articles [7439 Associated PubMed Articles listed on BioPortfolio]

Introduction of laryngeal mask airway in Japan, and its rescue use for newborns.

In neonatal resuscitation, laryngeal mask airway (LMA) is recommended when both face mask ventilation and endotracheal intubation fail. However, experience of LMA among obstetricians, nurses and midwi...

The boundary of holistic processing in the appraisal of facial attractiveness.

Facial attractiveness is often studied on the basis of the internal facial features alone. This study investigated how this exclusion of the external features affects the perception of attractiveness....

The Aging Face.

The aging face is a popular topic in modern medicine. To understand and treat unwanted signs of aging, it is imperative to understand the biological and physical causes and contributing factors to fac...

My true face: Unmasking one's own face representation.

Face recognition has been the focus of multiple studies, but little is still known on how we represent the structure of one's own face. Most of the studies have focused on the topic of visual and hapt...

Focusing on an illusion: accommodating to perceived depth?

Ocular accommodation potentially provides information about depth but there is little evidence that this information is used by the human visual system. We use the hollow-face illusion, an illusion of...

Medical and Biotech [MESH] Definitions

Counseling conducted via electronic or other non-face-to-face interactions.

Education via communication media (correspondence, radio, television, computer networks) with little or no in-person face-to-face contact between students and teachers. (ERIC Thesaurus, 1997)

The length of the face determined by the distance of separation of jaws. Occlusal vertical dimension (OVD or VDO) or contact vertical dimension is the lower face height with the teeth in centric occlusion. Rest vertical dimension (VDR) is the lower face height measured from a chin point to a point just below the nose, with the mandible in rest position. (From Jablonski, Dictionary of Dentistry, 1992, p250)

Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.

Skills, techniques, standards, and principles used to improve the art and symmetry of the teeth and face to improve the appearance as well as the function of the teeth, mouth, and face. (From Boucher's Clinical Dental Terminology, 4th ed, p108)

More From BioPortfolio on "Evaluating Modes of Influenza Transmission Between Humans"

Quick Search


Relevant Topics

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...

Searches Linking to this Trial