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Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure

2014-09-25 15:03:46 | BioPortfolio

Published on BioPortfolio: 2014-09-25T15:03:46-0400

Clinical Trials [1491 Associated Clinical Trials listed on BioPortfolio]

Assessment of TMAO Formation With Egg Intake Versus Choline Supplement in a Healthy Population

The objective of this study is to determine the effects of consuming either 3 eggs per day as compared to a daily choline supplement (choline bitartrate, 397.5 mg choline/day) on plasma co...

Choline Nutrition in Children With Cystic Fibrosis

Cystic fibrosis (CF) is the most common lethal, inherited disorder among Caucasians. Choline is an essential vitamin and as a methyl donor is critically needed to support the normal metabo...

Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans

The investigators are interested in learning more about choline, a nutrient required by the body. The body does make some choline, but it does not make enough to support health and the res...

Effect of Maternal Choline Intake on Choline Status and Health Biomarkers During Pregnancy and Lactation

The purpose of this study is to investigate the effect of varied maternal choline intake on maternal/fetal biomarkers of choline status, genomic expression and metabolomic profiling.

To Evaluate the Relative Abuse Potential of Hydrocodone Bitartrate and Acetaminophen

Evaluation of abuse potential in recreational abusers of Hydrocodone Bitartrate and Acetaminophen versus NORCO®.

PubMed Articles [6916 Associated PubMed Articles listed on BioPortfolio]

Long-term Physicochemical Stability of Concentrated Solutions of Noradrenaline Bitartrate in Polypropylene Syringes for Administration in the Intensive Care Unit.

Intensive care units use drug solutions within higher concentrations to avoid fluid overload. The purpose of this study was to evaluate the physicochemical stability of concentrated solutions of norad...

Effect of choline supplementation on neurological, cognitive and behavioral outcomes in offspring arising from alcohol exposure during development: A quantitative systematic review of clinical and preclinical studies.

Prenatal alcohol exposure results in cognitive, behavioral and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline...

Variations in plasma choline and metabolite concentrations in healthy adults.

Plasma concentrations of choline and its metabolites might serve as biomarkers for the health outcomes of several pathological states such as cardiovascular disease and cancer. However, information ab...

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP-Evoked Ca Signals through Sigma-1 Receptors.

Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate...

Plasma Betaine Is Positively Associated with Developmental Outcomes in Healthy Toddlers at Age 2 Years Who Are Not Meeting the Recommended Adequate Intake for Dietary Choline.

Choline is an important nutrient during development. However, there are limited data on dietary choline intake and status in toddlers and the relation to neurodevelopmental outcomes.

Medical and Biotech [MESH] Definitions

Donor of choline in biosynthesis of choline-containing phosphoglycerides.

An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. EC 2.7.1.32.

A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

An enzyme that catalyzes the transfer of cytidylate (CMP) to choline phosphate to form CDPcholine. It is the rate-limiting enzyme in the choline pathway for the biosynthesis of phosphatidylcholine. Its activity is increased by glucocorticoids. EC 2.7.7.15.

An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.

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