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Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity

2014-08-27 03:12:44 | BioPortfolio

Summary

Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in controlling the microbial colonization of the skin, thereby reducing proneness to secondary infections which typically cause sustained symptoms.

Thirty-nine infants with atopic dermatitis,randomized for a three-month-period in a double-blind design to receive extensively hydrolysed casein formula (NutramigenR, Mead-Johnson, USA) supplemented with (n=19) or without (n=20) Lactobacillus rhamnosus GG (ATCC 53103) 5.0 x 107 cfu/g to achieve a daily intake of 3.4 x 109 cfu.

Sampling (blood and faecal samples, cotton swab from the skin) and clinical examination of the infant, including SCORAD assessment to determine the severity of atopic dermatitis, at each study visit (at entry and one month and three months thereafter).

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Gut Microbiota

Intervention

Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG

Location

Turku University Central Hospital
Turku
Finland
20520

Status

Completed

Source

Turku University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:44-0400

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