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R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL

2014-08-27 03:12:44 | BioPortfolio

Summary

The study has the purpose to compare R-CHOP versus R-mini-CEOP in elderly patients (>65 years) with Diffuse Large B Cell Lymphoma (DLBCL).

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Elderly Patients (>65 Years)

Intervention

Cyclophosphamide, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, Prednisone, Epirubicin, Vinblastine, Rituximab, G-CSF

Location

Ospedale di Vigevano
Vigevano
Pavia
Italy
25123

Status

Completed

Source

Fondazione Intergruppo Italiano Linfomi Onlus

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:44-0400

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Medical and Biotech [MESH] Definitions

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.

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