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Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis

2014-08-27 03:12:44 | BioPortfolio

Summary

This trial is designed to evaluate olanzapine compared to the metoclopramide in the treatment of break through emesis after prophylaxis with dexamethasone, 5-HT 3 receptor antagonists and aprepitant in patients receiving chemotherapy. Efficacy will be assessed using a modified MASCC questionaire with a visual analog scale.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care

Conditions

Break Through Emesis After Prophylaxis With Dexamethasone, 5-HT 3RA and Aprepitant

Intervention

olanzapine, metoclopramide

Location

Martin-Luther-University Halle-Wittenberg, Department for Oncology and Hematology, Ernst-Grube-Strasse 40
Halle (Saale)
Sachsen-Anhalt
Germany
06097

Status

Not yet recruiting

Source

Martin-Luther-Universität Halle-Wittenberg

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:44-0400

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Medical and Biotech [MESH] Definitions

A dopamine D2 antagonist that is used as an antiemetic.

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

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Emesis and queasiness occurring after anesthesia.

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