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Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of LADA. Recently, research have found that being deficient of T-reg cells is an important cause of autoimmunity. The study hypothesis are as follow:
2. Patients with newly found diabetes type 1 have less T-reg than patients with long duration of the illness.
3. The number of T-reg is negative associated with HLA-risk-haplotype.
4. Same for LADA.
5. Differences relating to inflammatory cytokines will be seen among patients with newly found diabetes type 1, but not among others.
Research have worked out that b-cells are being destroyed by cytokines released from inflammatory cells. One hypothesis in that T-reg is a cause of autoimmunity, and that T-reg concentrations are low in patients with newly diagnosed diabetes type 1.
There will be taken blood samples from ten patients with newly diagnosed type 1 diabetes, LADA and type 1 diabetes older than 10 years and the same amount of samples from healthy, age- and sexmatched blood donors.
T-reg cells, inflammatory cytokines, HLA, anti-GAD, anti-IA2, white blood count, CRP, fasting C-peptide and HbA1c will be analyzed.
Our hypothesis is written above.
Observational Model: Cohort, Time Perspective: Prospective
Norwegian University of Science and Technology
Published on BioPortfolio: 2014-08-27T03:12:44-0400
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