Autoimmune Diabetes: Markers of the Disease and Treatment of Latent Autoimmune Diabetes of the Adults (LADA)

2014-08-27 03:12:44 | BioPortfolio


Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of LADA. Recently, research have found that being deficient of T-reg cells is an important cause of autoimmunity. The study hypothesis are as follow:

1. Patients with newly found diabetes type 1 have less T-reg than healthy.

2. Patients with newly found diabetes type 1 have less T-reg than patients with long duration of the illness.

3. The number of T-reg is negative associated with HLA-risk-haplotype.

4. Same for LADA.

5. Differences relating to inflammatory cytokines will be seen among patients with newly found diabetes type 1, but not among others.


Research have worked out that b-cells are being destroyed by cytokines released from inflammatory cells. One hypothesis in that T-reg is a cause of autoimmunity, and that T-reg concentrations are low in patients with newly diagnosed diabetes type 1.

There will be taken blood samples from ten patients with newly diagnosed type 1 diabetes, LADA and type 1 diabetes older than 10 years and the same amount of samples from healthy, age- and sexmatched blood donors.

T-reg cells, inflammatory cytokines, HLA, anti-GAD, anti-IA2, white blood count, CRP, fasting C-peptide and HbA1c will be analyzed.

Our hypothesis is written above.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Autoimmune Diabetes


Valdemar Grill




Norwegian University of Science and Technology

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:44-0400

Clinical Trials [1252 Associated Clinical Trials listed on BioPortfolio]

Imaging Inflammation in Autoimmune Diabetes

The purpose of this study is to determine whether magnetic resonance imaging (MRI) with ferumoxtran-10 can be used to detect changes in the pancreas associated with autoimmune diabetes.

Chicago Childhood Diabetes Registry

The goal of this study is to investigate the epidemiology and natural history of childhood-onset diabetes, whether of autoimmune, non-autoimmune, or mixed etiology in affected probands and...

Early Insulin Treatment in Patients With Latent Autoimmune Diabetes

Among adult patients diagnosed with type 2 diabetes, about 6% have autoantibodies directed against the insulin producing beta cells in the pancreas. These patients have a progressive beta...

Treatment of Latent Autoimmune Diabetes of the Adult

The purpose of the study is to clarify whether patients classified as Latent autoimmune diabetes of the adult (LADA)benefit from early treatment with insulin added to per oral treatment an...

Efficacy and Safety of Diamyd® in Patients With LADA (Latent Autoimmune Diabetes in Adult)

This is a randomized, placebo-controlled Multi-Center Phase II/III study to investigate if a prime and boost of 20ug Diamyd® (rhGAD65 formulated in Alhydrogel®), administered subcutaneou...

PubMed Articles [4835 Associated PubMed Articles listed on BioPortfolio]

Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.

A portion of adults with humoral immune changes have clinical diabetes that is initially not insulin-requiring (latent autoimmune diabetes of the adult, LADA). One of the genes strongly associated wit...

Lower mortality and cardiovascular event rates in patients with latent autoimmune diabetes in adults (LADA) as compared with type 2 diabetes and insulin deficient diabetes: A Cohort Study of 4,368 Patients.

Latent Autoimmune Diabetes in Adults (LADA) is the second most common form of diabetes, but data on its clinical course and prognosis are scarce. We compared long-term risk of mortality and cardiovasc...

Serum sclerostin and bone turnover in latent autoimmune diabetes in adults.

Bone formation is impaired in both type 1 and type 2 diabetes (T2D) while sclerostin, an antagonist of bone formation, is increased in T2D only. No data are available on latent autoimmune diabetes in ...

Diabetes Mellitus and Autoimmune Hepatitis: Demographical and Clinical Description of a Relatively Rare Phenotype.

We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. A total of 139 patients with diabetes an...

Vitamin D and Diabetes Mellitus.

Vitamin D has been suggested as a protective compound for diabetes mellitus. Several mechanisms linking vitamin D to the regulation of the immune response support a role for vitamin D in the pathogene...

Medical and Biotech [MESH] Definitions

Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.


Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).

The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

More From BioPortfolio on "Autoimmune Diabetes: Markers of the Disease and Treatment of Latent Autoimmune Diabetes of the Adults (LADA)"

Quick Search


Relevant Topics

Nephrology - kidney function
Nephrology is a specialty of medicine and pediatrics that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy (dialysis and kidney transplantation). Systemic conditions...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Trial