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Autoimmune Diabetes: Markers of the Disease and Treatment of Latent Autoimmune Diabetes of the Adults (LADA)

2014-08-27 03:12:44 | BioPortfolio

Summary

Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of LADA. Recently, research have found that being deficient of T-reg cells is an important cause of autoimmunity. The study hypothesis are as follow:

1. Patients with newly found diabetes type 1 have less T-reg than healthy.

2. Patients with newly found diabetes type 1 have less T-reg than patients with long duration of the illness.

3. The number of T-reg is negative associated with HLA-risk-haplotype.

4. Same for LADA.

5. Differences relating to inflammatory cytokines will be seen among patients with newly found diabetes type 1, but not among others.

Description

Research have worked out that b-cells are being destroyed by cytokines released from inflammatory cells. One hypothesis in that T-reg is a cause of autoimmunity, and that T-reg concentrations are low in patients with newly diagnosed diabetes type 1.

There will be taken blood samples from ten patients with newly diagnosed type 1 diabetes, LADA and type 1 diabetes older than 10 years and the same amount of samples from healthy, age- and sexmatched blood donors.

T-reg cells, inflammatory cytokines, HLA, anti-GAD, anti-IA2, white blood count, CRP, fasting C-peptide and HbA1c will be analyzed.

Our hypothesis is written above.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Autoimmune Diabetes

Location

Valdemar Grill
Trondheim
Norway
7030

Status

Recruiting

Source

Norwegian University of Science and Technology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:44-0400

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Medical and Biotech [MESH] Definitions

Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.

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Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).

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A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

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