A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis
Published on BioPortfolio: 2014-10-13T19:03:39-0400
Clinical Trials
Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial)
TNF alpha Inhibitors have been very effective in treating rheumatologic diseases as well as uveitis. Adalimumab is the first member of a new class of TNF antibody compounds developed to co...
Intravitreal Adalimumab Versus Subcutaneous Adalimumab in Non-infectious Uveitis
The objective of this study is to compare and evaluate the efficacy of subcutaneous (40mg) adalimumab biweekly injections to intravitreal adalimumab (1.5 mg/ 0.03 mL) administration, given...
Adalimumab (Humira) in the Treatment of Refractory Non-infectious Uveitis
The purpose of this study is to assess the safety and efficacy of Adalimumab in uveitis.
Direct intravitreal administration of medication is the preferred method of treatment for uveitis and retinal vascular disorders. The eye is a self contained organ relatively isolated from...
A Study of the Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis
A study comparing the safety and efficacy Adalimumab vs. Placebo in subjects with inactive uveitis.
PubMed Articles
INFLIXIMAB and ADALIMUMAB in Uveitic Macular Edema.
To compare the efficacy of infliximab and adalimumab in patients with refractory uveitis-related macular edema (ME).
Reclassifying Idiopathic Uveitis: Lessons from a Tertiary Uveitis Center.
Idiopathic uveitis is frequently the most common diagnosis in series from uveitis clinics. We sought to determine the percentage of patients initially diagnosed as idiopathic, non-infectious uveitis r...
Optimising drug therapy for non-infectious uveitis.
Uveitis encompasses a wide variety of sight-threatening diseases characterized by intraocular inflammation. It is often classified as infectious and non-infectious uveitis. Unlike infectious uveitis, ...
Case reports indicated that HIV itself may be a direct cause of uveitis. However, the association of HIV with incident uveitis has not been extensively studied. This nationwide cohort study determined...
Nearly one-half of all uveitis cases seen at tertiary referral centers have no identifiable cause. Many systemic, paraocular, intraocular, topical medications, and even vaccines can induce intraocular...
Medical and Biotech [MESH] Definitions
Hla-b27 Antigen
Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.
Uveitis, Posterior
Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis.
Adalimumab
A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS.
Uveitis, Intermediate
Inflammation of the pars plana, ciliary body, and adjacent structures.
Ocular Hypotension
Abnormally low intraocular pressure often related to chronic inflammation (uveitis).
