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Acute Response Capsaicin Flare Study

2014-08-27 03:12:48 | BioPortfolio

Summary

Prior to administering PF-04427429 to patients we wish to increase the understanding of functional effects associated with calcitonin gene related peptide (CGRP) pathways. This study will examine whether it is possible for a single dose of PF-04427429 to acutely attenuate a capsaicin induced flare response. This will contribute to 'Proof of Mechanism' for this molecule and data from this study will help inform dose setting on the future phase II clinical trials.

Description

Proof of mechanism in healthy volunteers

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Conditions

Healthy

Intervention

PF-04427429, Capsaicin challenge, Placebo, Capsaicin challenge, EMLA positive control

Location

Pfizer Investigational Site
Bruxelles
Belgium
B-1070

Status

Not yet recruiting

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:48-0400

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Medical and Biotech [MESH] Definitions

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

The organization, management, and assumption of risks of a business or enterprise, usually implying an element of change or challenge and a new opportunity.

Undertaking a task involving a challenge for achievement or a desirable goal in which there is a lack of certainty or a fear of failure. It may also include the exhibiting of certain behaviors whose outcomes may present a risk to the individual or to those associated with him or her.

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.

A plant genus of the family SOLANACEAE. The hot peppers yield CAPSAICIN, which activates vanilloid receptors. Several varieties have sweet or pungent edible fruits that are used as vegetables when fresh and spices when the pods are dried.

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