Advertisement

Topics

Acute Response Capsaicin Flare Study

2014-08-27 03:12:48 | BioPortfolio

Summary

Prior to administering PF-04427429 to patients we wish to increase the understanding of functional effects associated with calcitonin gene related peptide (CGRP) pathways. This study will examine whether it is possible for a single dose of PF-04427429 to acutely attenuate a capsaicin induced flare response. This will contribute to 'Proof of Mechanism' for this molecule and data from this study will help inform dose setting on the future phase II clinical trials.

Description

Proof of mechanism in healthy volunteers

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Conditions

Healthy

Intervention

PF-04427429, Capsaicin challenge, Placebo, Capsaicin challenge, EMLA positive control

Location

Pfizer Investigational Site
Bruxelles
Belgium
B-1070

Status

Not yet recruiting

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:48-0400

Clinical Trials [1392 Associated Clinical Trials listed on BioPortfolio]

A Study To Assess The Effect Of 498 In A Capsaicin Challenge Model

This study is designed to look at the affect of 498 on rhinitis symptoms, as induced by capsaicin challenge

Capsaicin in Treatment of Rhinogenic Headache

Description: Capsaicin (8- methyl-N-vanillyl-6-nonenamide) has been demonstrated to have a therapeutic effect in idiopathic rhinitis. We hypothesize that capsaicin has a therapeutic effect...

ToAST:Investigating the Effect of Bronchial Thermoplasty on Cough in Patients With Severe Asthma

ToAST study is a pilot study aiming to establish the safety profile of using inhaled capsaicin challenge in patients with severe asthma. The investigators will also explore the differences...

Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects

The purpose of this research is to study how people respond differently to capsaicin in different racial groups and the effect it has on your pain levels. Capsaicin is a natural product ma...

Effects of Capsaicin on the Structure, Distribution, and Function of Cutaneous Small Nerve Fibers in Psoriatic Skin

The purpose of this research study is to examine the role of nerves in the skin in psoriasis and to better understand the effects of capsaicin in psoriasis.In this study, capsaicin will be...

PubMed Articles [9609 Associated PubMed Articles listed on BioPortfolio]

Capsaicin alleviates hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.

Capsaicin has anti-inflammatory and antioxidant effects, as well as some benefits on the cardiovascular system. The exact effects of capsaicin on atherosclerosis are poorly understood. To investigate ...

0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial.

A randomized, double-blinded, crossover, placebo controlled trial was conducted to evaluate the efficacy and safety of 0.075% capsaicin lotion for treating painful diabetic neuropathy (PDN).

Capsaicin produces antidepressant-like effects in the forced swimming test and enhances the response of a sub-effective dose of amitriptyline in rats.

Transient receptor potential vanilloid 1 (TRPV1) channels have been implicated in depression and anxiety. The aim of this study was to evaluate the antidepressant-like properties of the TRPV1 agonist ...

Anti-pruritic effect of topical capsaicin against histamine-induced pruritus on canine skin.

Several human studies have reported that capsaicin has anti-pruritic effects. Moreover, sever- al concentrations of topical capsaicin have been used to alleviate itch. The aim of this study was to inv...

Intermittent sprint performance in the heat is not altered by augmenting thermal perception via L-menthol or capsaicin mouth rinses.

Cooling sensations elicited by mouth rinsing with L-menthol have been reported as ergogenic. Presently, responses to L-menthol mouth rinsing during intermittent sprint performance (ISP) in the heat ar...

Medical and Biotech [MESH] Definitions

An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

The organization, management, and assumption of risks of a business or enterprise, usually implying an element of change or challenge and a new opportunity.

Undertaking a task involving a challenge for achievement or a desirable goal in which there is a lack of certainty or a fear of failure. It may also include the exhibiting of certain behaviors whose outcomes may present a risk to the individual or to those associated with him or her.

A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.

A plant genus of the family SOLANACEAE. The hot peppers yield CAPSAICIN, which activates vanilloid receptors. Several varieties have sweet or pungent edible fruits that are used as vegetables when fresh and spices when the pods are dried.

More From BioPortfolio on "Acute Response Capsaicin Flare Study"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

The Top 100 Pharmaceutical Companies
Top 10 biotech and pharmaceutical companies worldwide based on market value in 2015 2015 ranking of the global top 10 biotech and pharmaceutical companies based on revenue (in billion U.S. dollars) Johnson & Johnson, U.S. 74...


Searches Linking to this Trial