A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI)

2010-07-15 17:00:00 | BioPortfolio


The study primary objective is to compare the clinical efficacy of two formulations in the supportive treatment of lactose intolerance.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment






Instituto Goiano de Gastroenterologia


Not yet recruiting


Eurofarma Laboratorios Ltda

Results (where available)

View Results


Published on BioPortfolio: 2010-07-15T17:00:00-0400

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PubMed Articles [14 Associated PubMed Articles listed on BioPortfolio]

The influence of the vitamin D3 level in the blood serum of lactase gene polymorphism on the development of chronic polypous rhinosinusitis.

The objective of the present study was to elucidate the possible correlations between the vitamin D level in the blood serum and lactase gene polymorphism (LCT-13910 T>C) in the patients presenting wi...

Association between functional lactase variants and a high abundance of Bifidobacterium in the gut of healthy Japanese people.

Previous studies have shown that Japanese people exhibit a higher abundance of Bifidobacterium compared to people from other countries. Among the possible factors affecting the gut microbiota composit...

Analysis of lactase in lactose intolerance supplements.

Lactase is the enzyme responsible for the digestion of the disaccharide lactose, and deficiency in this enzyme causes the prevalent medical condition lactose intolerance. Management of lactose intoler...

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There have been few reports on lactase deficiency (LD) and lactose intolerance (LI) in Malaysia, which has a peculiar mix of three distinct major Asian races-Malay, Chinese, and Indian. The aim of thi...

Spray congealed lipid microparticles for the local delivery of β-galactosidase to the small intestine.

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Medical and Biotech [MESH] Definitions

An enzyme which catalyzes the hydrolysis of LACTOSE to D-GALACTOSE and D-GLUCOSE. Defects in the enzyme cause LACTOSE INTOLERANCE.

The enzyme hydrolyzing glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. It also catalyzes the hydrolysis of phlorizin to phloretin and glucose. It is found in the intestinal brush border membrane often in conjunction with lactase. EC

Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.

The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.

The multifunctional protein that contains two enzyme domains. The first domain (EC hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.

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