Comparison of Biliary Forceps Biopsy and Brush Cytology

2014-08-27 03:12:50 | BioPortfolio


Cholangiocarcinomas (CCCs) are malignant tumors arising from the biliary epithelium. CCCs are characterised by a high mortality and the only curable therapy is complete tumor resection, if feasible, or in some cases liver transplantation. Since surgery for CCC is a procedure associated with a high mortality itself it needs to be ascertained that an accurate preoperative diagnosis has been established. However, it often appears to be difficult to get a preoperative pathological diagnosis, since it is difficult to obtain tumor specimens using cytologic brushings, biopsy forceps, bile aspiration or endoscopic ultrasonography guided-fine needle aspiration. This is reflected by a nearly 100% specificity but low sensitivity rates.

The aim of this study is to compare a new method of biliary biopsy using a double-balloon enteroscopy (DBE) forceps to enable a safe and reliable tissue specimen collection within the proximal biliary tract with cytology brushings in patients with suspected malignant proximal biliary strictures.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic




double-balloon enteroscopy forceps biopsy, Transpapillary brush cytology


Department of Internal Medicine I, Ulm University Hospital




University of Ulm

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:50-0400

Clinical Trials [1004 Associated Clinical Trials listed on BioPortfolio]

Hot and Cold Biopsy Forceps in the Diagnosis of Endobronchial Lesions

A new electrocautery bronchoscopy biopsy forceps is now commercially available and may prevent bleeding following biopsy. Only one study used this device wherein the authors concluded that...

ERC Via Double-Balloon-Enteroscopy in Patients With Biliodigestive Anastomosis

In patients with biliodigestive anastomosis direct cholangiography (ERC) is due to changed anatomy commonly not possible. The aim of the study is to test the feasibility to perform direct ...

Balloon-assisted Enteroscopy and Bacteria

1. Balloon-assisted enteroscopy (BAE) is a new tool to investigate small intestinal diseases. 2. Deep enteroscopy made possible by balloon expansion and manipulation of small ...

The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Registry

The purpose of this study is to create a registry (collect data and keep it in a research database) to learn more about two methods of taking small tissue samples from your esophagus (the ...

Double/Single Balloon Enteroscopy Stiffening Wire RCT

This is a randomized clinical trial examining the use of a stiffening wire to increase depth of maximal insertion during double and single balloon enteroscopy.

PubMed Articles [4446 Associated PubMed Articles listed on BioPortfolio]

Characteristics of Crohn's disease under 
double balloon enteroscopy.

To observe ulcer characteristics of Crohn's disease under double balloon enteroscopy, and to evaluate the correlation between endoscopic severity and clinical manifestations.
 Methods: A prospective...

Clinical utility of novel ultrathin single-balloon enteroscopy: a feasibility study.

 The advent of balloon-assisted enteroscopy (BAE) has facilitated the examination of the entire digestive tract. However, using a rigid sliding tube during the procedure reduces patient acceptance. ...

First report of a secondary aortojejunal fistula diagnosed by double-balloon enteroscopy.

Liquid-based oral brush cytology in the diagnosis of oral leukoplakia using a modified Bethesda Cytology system.

This study aims to develop diagnostic criteria to identify oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) using oral liquid-based brush cytology (OLBC), and to co...

Bowel Preparation With Polyethylene Glycol 3350 or Fasting Only Before Peroral Single-balloon Enteroscopy: A Randomized European Multicenter Trial.

Although bowel preparation before colonoscopy and capsule endoscopy is widely evaluated and usually follows established guidelines, a standard preparation regime for peroral small bowel enteroscopy is...

Medical and Biotech [MESH] Definitions

A balloon-assisted enteroscopy utilizing a flexible endoscope with one overtube balloon control unit.

Endoscopy of the small intestines accomplished while advancing the endoscope into the intestines from the stomach by alternating the inflation of two balloons, one on an innertube of the endoscope and the other on an overtube.

An endoscopy of the small intestines accomplished while advancing the endoscope, which is assisted by one or two balloons

The use of balloon CATHETERS to remove emboli by retraction of the balloon that is inflated behind the EMBOLUS.

Widening of a stenosed HEART VALVE by the insertion of a balloon CATHETER into the valve and inflation of the balloon.

More From BioPortfolio on "Comparison of Biliary Forceps Biopsy and Brush Cytology"

Quick Search


Relevant Topics

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Searches Linking to this Trial