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Comparison of Biliary Forceps Biopsy and Brush Cytology

2014-08-27 03:12:50 | BioPortfolio

Summary

Cholangiocarcinomas (CCCs) are malignant tumors arising from the biliary epithelium. CCCs are characterised by a high mortality and the only curable therapy is complete tumor resection, if feasible, or in some cases liver transplantation. Since surgery for CCC is a procedure associated with a high mortality itself it needs to be ascertained that an accurate preoperative diagnosis has been established. However, it often appears to be difficult to get a preoperative pathological diagnosis, since it is difficult to obtain tumor specimens using cytologic brushings, biopsy forceps, bile aspiration or endoscopic ultrasonography guided-fine needle aspiration. This is reflected by a nearly 100% specificity but low sensitivity rates.

The aim of this study is to compare a new method of biliary biopsy using a double-balloon enteroscopy (DBE) forceps to enable a safe and reliable tissue specimen collection within the proximal biliary tract with cytology brushings in patients with suspected malignant proximal biliary strictures.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Cholangiocarcinoma

Intervention

double-balloon enteroscopy forceps biopsy, Transpapillary brush cytology

Location

Department of Internal Medicine I, Ulm University Hospital
Ulm
BW
Germany
89081

Status

Completed

Source

University of Ulm

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:50-0400

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