Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use

2014-08-27 03:12:56 | BioPortfolio


Narcotic pain medicines bind mu-opioid receptors in the bowel and delay the return of normal function. Alvimopan is a peripherally acting mu-opioid receptor antagonist that blocks mu-opioid receptors in the gastrointestinal (GI) tract but does not compromise central nervous system-mediated opioid-based analgesia. Length of stay (LOS) is an important surrogate measure of quality after colon surgery and the most common reason for prolonged LOS after abdominal surgery is delayed GI recovery (postoperative ileus).

The Food and Drug Administration (FDA) has approved alvimopan (dosed preoperatively and twice daily postoperatively for up to 15 in-hospital doses) for the acceleration of upper and lower GI recovery after partial bowel resection with primary anastomosis. In the 5 phase III alvimopan efficacy trials, a simple standardized accelerated postoperative care pathway was used rather than a comprehensive, multidisciplinary colon surgery (MDCS) care process model that is used by Intermountain Healthcare. In the most recently completed alvimopan phase III trial, the mean postoperative LOS was 5.2 days whereas the mean LOS at Intermountain Healthcare is 4.4 days without the addition of alvimopan to the MDCS care process model.

This trial will investigate if the addition of alvimopan to the Intermountain Healthcare MDCS care process can decrease LOS compared with the MDCS care process plus placebo.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment




Treatment Group, Control Group


American Fork Hospital
American Fork
United States




Intermountain Health Care, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:56-0400

Clinical Trials [6572 Associated Clinical Trials listed on BioPortfolio]

Interventions to Decrease the Impact of Post OPerative Ileus After Liver Transplant or Resection Surgery

This is a randomized controlled trial to assess ways to address post-operative ileus (POI) in adult patients on the liver transplant service undergoing either liver transplant or resection...

Alvimopan as Rescue in Post op Ileus

This will be a prospective randomized control trial with a total of 142 patients. Patients who undergo laparoscopic or open colorectal resection, small bowel resection, or ileostomy revers...

Does Chewing Gum After Elective Laparoscopic Colectomy Surgery Decrease Ileus?

The incidence of ileus after laparoscopic colectomy continues to pose complications for the patient, staff, and the healthcare system. Postoperative ileus remains a source of morbidity and...

The Effect of Coffee After Resection of Small Bowel

Post-operative ileus ("post-op ileus") is a condition which can occur after surgery. This means that the bowels stop working correctly and food and liquids will not pass through in the nor...

Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries

This is a randomized, placebo-controlled, double-blinded trial. Forty patients will be randomized into two groups. The subjects in the Treatment Group will be administered with lithium ...

PubMed Articles [32828 Associated PubMed Articles listed on BioPortfolio]

A pilot study of acupuncture at pain acupoints for cervical cancer pain.

This retrospective study aimed to investigate the feasible effectiveness of acupuncture at pain acupoints for the treatment of patients with cervical cancer pain (CCP). A total of 64 cases were analyz...

Preservation of previously frozen black wildebeest meat (Connochaetes gnou) using oregano (Oreganum vulgare) essential oil.

The effect of oregano essential oil (1% v/v) on the shelf-life of black wildebeest Biceps femoris (BF) muscles stored aerobically at 2.6 ± 0.6 °C was investigated by evaluating changes in pH, ...

Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression.

Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression (PSD) were investigated. A total of 78 PSD patients were selected in Binzhou City Center H...

Ultrasound Combined With Microbubbles Increase the Delivery of Doxorubicin by Reducing the Interstitial Fluid Pressure.

The aims of this study were to determine the change of interstitial fluid pressure (IFP) after therapy using pulsed low-frequency ultrasound combined with microbubbles and to determine the change of d...

Experimental animal study of docetaxel combined with carboplatin in the treatment of retinoblastoma.

The synergistic effects of docetaxel (DTX) combined with carboplatin in the treatment of retinoblastoma (RB) was explored in mouse RB xenografts compared with carboplatin alone and DTX alone groups. R...

Medical and Biotech [MESH] Definitions

A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group acceptor. EC 2.7.3.

The informal or formal organization of a group of people based on a network of personal relationships which is influenced by the size and composition, etc., of the group.

A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1.

More From BioPortfolio on "Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use"

Quick Search


Relevant Topics

Pain is defined by the International Association for the Study of Pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. Some illnesses can be excruci...

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Searches Linking to this Trial