Advertisement

Topics

Effect of Apple and Apple Pomace on Inflammation and Cholesterol Metabolism in Healthy Overweight

2014-08-27 03:13:01 | BioPortfolio

Summary

The investigators will assess the protective and antiinflammatory effects of processed fruit and fruit fibre in overweight subjects with signs of metabolic syndrome. A single-blinded parallel study is conducted to investigate the protective effects of fruit fibre on colonic epithelium. Relevant signalling pathways related to cholesterol metabolism, vascular inflammation, oxidative defence, apoptosis and sterol metabolism will be targeted. Volunteers are randomly assigned one of three groups. They are instructed to follow a polyphenol and pectin restricted diet for six weeks. The last four weeks in this six week period, the restricted diet is supplemented with whole apples (550g/day), apple pomace (22g/day) or nothing. Blood, urine, faecal samples and colon biopsies are collected before and after the four weeks intervention period.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Prevention

Conditions

Cardiovascular Diseases

Intervention

Apples, Apple pomace

Location

Department of Human Nutrition, LIFE, University of Copenhagen
Frederiksberg
Denmark
1951

Status

Active, not recruiting

Source

University of Copenhagen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:01-0400

Clinical Trials [1349 Associated Clinical Trials listed on BioPortfolio]

Effects of Beverages Containing Orange or Apple Pomace on Digestive Health in Adults

This is a randomized crossover intervention designed to evaluate effects of daily intake of beverages containing orange or apple Pomace on gastrointestinal function as measured by stool fr...

Effect of Apples on cardioVascular Risk And Gut Health

There is now considerable scientific evidence that a diet rich in fruits and vegetables could improve human health. Apples are among the most frequently consumed fruits in the world. Epide...

Effect of Ingesting a Tomato Pomace Extract on Platelet Aggregation

This study evaluates the acute and longer term effects of a tomato pomace extract on platelet aggregation in health subjects.

Obesity-related Health Benefits of Apples

Obesity is characterized by an underlying inflammatory state in which various inflammatory signaling molecules, termed cytokines, affect metabolic processes central to type 2 diabetes and ...

Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study

Different physical form of apples had a significant effect on satiety and blood sugar levels which was shown in a 1977 study by Haber and his team (Haber et al.1977).It was suggested that ...

PubMed Articles [11775 Associated PubMed Articles listed on BioPortfolio]

Upgrading Pectin Production from Apple Pomace by Acetic Acid Extraction.

Pectin, as one of the most widely used functional polysaccharide, can be abundantly extracted from apple pomace which is the main by-product of apple juice industry. In the case of 110 min, 10% (w/w)...

Control of Listeria monocytogenes in Caramel Apples by Use of Sticks Pretreated with Potassium Sorbate.

A multistate listeriosis outbreak associated with caramel apples from 2014 to 2015 prompted research on the survival of Listeria monocytogenes in fresh apples and caramel apples. Research indicated th...

Fiber-Rich Food Processing Byproducts Enhance the Expansion of Cornstarch Extrudates.

Expansion characteristics of cornstarch-based extrudates incorporating fiber-rich food processing byproducts was explored. Waxy and regular cornstarch were used as the base materials with apple pomace...

The Incidence of Delayed-Type Hypersensitivity Reactions to Apples Among Patients Allergic to Birch Pollen.

The major apple allergen Mal d 1 cross-reacts with the homologous birch pollen allergen Bet v 1 and causes immunoglobulin E (IgE)-mediated immediate-type allergic reactions. In some patients, delayed-...

Enhanced Stability of Red-Fleshed Apple Anthocyanins by Copigmentation and Encapsulation.

Red-fleshed apples are a great source of natural colorants and functional food ingredients because of their high anthocyanins content. Generally, anthocyanins are highly unstable after extraction, whi...

Medical and Biotech [MESH] Definitions

Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.

Diseases of long duration and generally slow progression. The four main types of noncommunicable diseases are CARDIOVASCULAR DISEASES (e.g., heart attacks and stroke), CANCER, chronic respiratory diseases (e.g., CHRONIC OBSTRUCTIVE PULMONARY DISEASE and ASTHMA) and DIABETES MELLITUS.

A natural dihydrochalcone found in apples and many other fruits.

Antioxidant; also a post-harvest dip to prevent scald on apples and pears.

More From BioPortfolio on "Effect of Apple and Apple Pomace on Inflammation and Cholesterol Metabolism in Healthy Overweight"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Obesity
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...


Searches Linking to this Trial