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Real-world Effectiveness and Cost-effectiveness of Leading Inhaled Corticosteroids in Asthma Management

2014-08-27 03:13:01 | BioPortfolio

Summary

The objective of the study was to compare the effectiveness, cost-effectiveness and direct healthcare costs of managing asthma in patients with evidence of persistent asthma, following the initiation and increased dose of inhaled corticosteroid (ICS) therapy using HFA-BDP (Qvar®) (either as initial therapy or as a step-up therapy) compared with the most commonly prescribed alternative ICS in the UK, CFC-beclometasone (BDP) and fluticasone (FP) as metered dose inhalers (MDIs).

Description

While current UK asthma guidelines are underpinned with evidence from RCTs, much of this evidence has been undertaken in patients who are not representative of the majority of the current UK asthma population. In fact it has been estimated that fewer than 10% of the patients seen in everyday clinical practice would be eligible for inclusion in such trials. The poor representation of the asthma population is due to a number of factors, such as tightly-controlled inclusion criteria for RCTs. There is therefore a need for more representative RCTs and real-life and observational studies to inform existing guidelines and help optimise asthma outcomes. A more holistic approach to respiratory research would see RCT evidence complimented by "real-life" data from pragmatic trials and observational studies.

A number of trends are emerged in asthma prescribing that warrant further investigation to ascertain their benefit to both the patient and the NHS. In particular, significant pressure exists to use the cheapest inhaler devices and formulations. An analysis of a pragmatic trial of Qvar versus standard CFC-BDP undertaken by Research in Real Life suggested that Qvar may be offer greater effectiveness in.5,6 In light of these data, the following report details the findings of a study designed to examine the effectiveness of Qvar in real-life clinical practice using the General Practice Research Database (GPRD).

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Asthma

Intervention

Extra-fine hydrofluoroalkane-beclomethasone dipropionate, Extra-fine hydrofluoroalkane-beclomethasone dipropionate, Fluticasone propionate, Beclomethasone dipropionate, fluticasone propionate, Chlorofluorocarbon beclomethasone dipropionate

Location

General Practice Research Database
London
United Kingdom
SW8 5NQ

Status

Completed

Source

Research in Real-Life Ltd

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:01-0400

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PubMed Articles [1946 Associated PubMed Articles listed on BioPortfolio]

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Atopic dermatitis (AD) is associated with increased bacterial colonization and infection of skin, and multiple risk factors for extra-cutaneous infections. However, previous studies found conflicting ...

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The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an ap...

"How do you know those particles are from cigarettes?": An algorithm to help differentiate second-hand tobacco smoke from background sources of household fine particulate matter.

Second-hand smoke (SHS) at home is a target for public health interventions, such as air quality feedback interventions using low-cost particle monitors. However, these monitors also detect fine parti...

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Medical and Biotech [MESH] Definitions

Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.

Conducting a fine needle biopsy with the aid of ENDOSCOPIC ULTRASONOGRAPHY.

Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)

A plant genus of the family BOMBACACEAE. The fine silky hairs covering the seeds have been used for floatation, stuffing, and insulation.

A name originally applied to a group of skin diseases characterized by the formation of fine, branny scales, but now used only with a modifier. (Dorland, 27th ed)

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