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Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis

2014-07-23 21:08:50 | BioPortfolio

Summary

This study focuses on the relationship between prophylaxis antibiotics and frequency of urinary tract infection in children diagnosed with antenatal hydronephrosis. Hydronephrosis is the most common fetal abnormality occurring in 1-5% of all pregnancies. Currently, with the widespread accessibility of antenatal ultrasound across cities in Ontario, the detection of hydronephrosis has become even more common. As a result, thousands of infants with hydronephrosis have been seen and managed by pediatricians, pediatric nephrologists, pediatric urologists, and family physicians. The investigators need to determine if antibiotic prophylaxis is effective in reducing the number of urinary tract infections in this population.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Hydronephrosis

Intervention

Trimethoprim, Simple Syrup

Location

McMaster Children's Hospital
Hamitlon
Ontario
Canada
L8N 3Z5

Status

Not yet recruiting

Source

McMaster University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:50-0400

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Minimizing the Utilization of Voiding Cystourethrography for Patients With Antenatal Hydronephrosis

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The purpose of the study is to determine the glycemic index and the insulinemic index of a sweetener syrup

PubMed Articles [3723 Associated PubMed Articles listed on BioPortfolio]

A trimethoprim conjugate of thiomaltose has enhanced antibacterial efficacy in vivo.

Trimethoprim is one of the most widely used antibiotics in the world. However its efficacy is frequently limited by its poor water solubility and dose limiting toxicity. Prodrug strategies based on co...

Parapelvic cysts mimicking hydronephrosis.

Point-of-care renal ultrasonography performed by physicians at bedside assists in rapid evaluation of hydronephrosis, nephrolithiasis and other structural abnormalities, and guides management. As such...

Malrotated kidney causing prenatal giant hydronephrosis.

We report the case of a malrotated right kidney associated with giant prenatal hydronephrosis due to a non vascular extrinsic ureteropelvic compression. The kidney presented an hyper-rotation of 180°...

Process optimization of the extraction condition of β-amylase from brewer's malt and its application in the maltose syrup production.

β-amylase is of important biotechnological aid in maltose syrup production. In this study, the extraction condition of β-amylase from brewer's malt and the optimal dosage of β-amylase in maltose sy...

The Correlation Between Serial Ultrasound and Diuretic Renography in Children with Severe Unilateral Hydronephrosis.

While serial renal ultrasound is often used as an alternative to functional renal imaging among children followed for hydronephrosis, it is unclear whether a lack of hydronephrosis progression safegua...

Medical and Biotech [MESH] Definitions

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Nonsusceptibility of bacteria to the action of TRIMETHOPRIM.

Syrup made from corn used widely in foods and beverages as a cheaper alternative sweetener to SUCROSE (common table sugar). It is generated by enzymatic processing of natural corn syrup to produce a liquid most widely composed of 42 or 55% FRUCTOSE, GLUCOSE, and various POLYSACCHARIDES.

A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha and C. acuminata. They contain EMETINE, cephaeline, psychotrine and other ISOQUINOLINES. Ipecac syrup is used widely as an emetic acting both locally on the gastric mucosa and centrally on the chemoreceptor trigger zone.

Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.

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