Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis

2014-07-23 21:08:50 | BioPortfolio


This study focuses on the relationship between prophylaxis antibiotics and frequency of urinary tract infection in children diagnosed with antenatal hydronephrosis. Hydronephrosis is the most common fetal abnormality occurring in 1-5% of all pregnancies. Currently, with the widespread accessibility of antenatal ultrasound across cities in Ontario, the detection of hydronephrosis has become even more common. As a result, thousands of infants with hydronephrosis have been seen and managed by pediatricians, pediatric nephrologists, pediatric urologists, and family physicians. The investigators need to determine if antibiotic prophylaxis is effective in reducing the number of urinary tract infections in this population.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment




Trimethoprim, Simple Syrup


McMaster Children's Hospital
L8N 3Z5


Not yet recruiting


McMaster University

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:08:50-0400

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