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Pharmacokinetic Interaction Between Maraviroc And Fosamprenavir/Ritonavir In Healthy Subjects

2014-08-27 03:13:03 | BioPortfolio

Summary

This is will be an open-label, fixed-sequence, multiple dose crossover study in 2 cohorts of 14 healthy male and/or female subjects, to estimate the effect of maraviroc on the pharmacokinetics of amprenavir and ritonavir and fosamprenavir/ritonavir on the pharmacokinetics of maraviroc.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Healthy

Intervention

Maraviroc, Fosamprenavir/ritonavir, Maraviroc + Fosamprenavir/ritonavir, Maraviroc, Fosamprenavir/ritonavir, Maraviroc + Fosamprenavir/ritonavir

Location

Pfizer Investigational Site
Singapore
Singapore
188770

Status

Not yet recruiting

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:03-0400

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PubMed Articles [55 Associated PubMed Articles listed on BioPortfolio]

No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV-1-Infected Subjects.

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Medical and Biotech [MESH] Definitions

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV.

An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.

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