Rapid Detection of Staphylococcus Aureus in Burn Patients
Summary
The purpose of this study is to determine if rapid early detection of the bacteria causing sepsis in burn patients improves patient outcomes.
Description
Burn patients have lost their primary barrier to microorganism invasion and therefore are continually and chronically exposed to pathogens. Ninety-seven percent of patients with >20% total body surface area (TBSA) burns develop septicemia; predominantly involving gram positive cocci including MRSA and methicillin sensitive Staphylococcus aureus. Blood culture (BC) is the traditional detection method for septicemia. However, antibiotics and inadequate sample volumes can impair detection by BC and results can take 3-4 days.
Polymerase chain reaction (PCR) represents a potential adjunct to BC. Pathogens are detected in a growth-independent manner by targeting their genetic make-up. Quantitative determining of pathogen DNA using PCR could aid in determining antimicrobial drug therapy efficacy by providing results on the same testing day as opposed to 3-4 days with BC. PCR may also detect persistent infections during antimicrobial therapy when culture samples are inhibited.
The aims of this study are:(1)to correlate quantitative PCR results with that of the BC; (2) to test the clinical application of PCR results with clinical outcomes of treatment of presumptive diagnosis of staphylococcal sepsis.
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Conditions
Burns
Intervention
PCR test
Location
University of California Davis Medical Center-Regional Burn Center
Sacramento
California
United States
95817
Status
Enrolling by invitation
Source
American Burn Association
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01140269
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:13:03-0400
Clinical Trials
Low-Dose Hydrocortisone in Acutely Burned Patients
Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those...
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adult patients with partial deep dermal and full thickness bur...
The Effects of Hyperbaric Oxygen Therapy (HBOT) on Acute Thermal Burns
The blinded RCTstudy aims to: - Determine the effects of HBOT on burns conversion for patients who have fresh thermal burns injury using the LDI. - Objectively determine...
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in children with partial deep dermal and full thickness burns.
The Role of Amniotic Membrane Transplantation in Ocular Chemical Burns
This is a randomized clinical trial study to identify the role of AMT (amniotic membrane transplantation) in treating epithelial defect, symblepharon prevention preventing corneal vascular...
PubMed Articles
Chinese burn referral criteria (2018 version).
There is no national referral criteria for burns in China till now, which brings inconvenience and confusion. Based on the oversea experiences and the actual situation in China, many famous experts in...
Health Related Quality of Life in Children After Burn Injuries: A Systematic Review.
Through improved survival of burns, more children have to deal with consequences of burns. Health-related quality of life (HRQL) measurement is important to qualify the perceived burden of burns in ch...
The Department of Burns and Plastic Surgery of Provincial Hospital Affiliated to Shandong University is the leading team in Shandong province. It is integrated with clinical treatment, scientific rese...
Attribution bias underlying burns-induced anxiety symptoms.
Burn injuries are a debilitating cause of morbidity and mortality associated with the long-term impact of psychological factors on quality of life. Accurate assessment of the differential impact of bu...
Barriers to adequate first-aid for paediatric burns at the scene of the injury.
The recommended first-aid for burns, consisting of 20 minutes of cool running water (CRW) delivered within three hours of injury, offers a simple yet effective means of improving health outcomes. The ...
Medical and Biotech [MESH] Definitions
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Burns, Inhalation
Burns of the respiratory tract caused by heat or inhaled chemicals.
Burns, Chemical
Burns caused by contact with or exposure to CAUSTICS or strong ACIDS.
Burns, Electric
Burns produced by contact with electric current or from a sudden discharge of electricity.
Rorschach Test
A projective test used to evaluate a broad range of personality variables including pathology of thought and perception. The subject's responses to inkblot prints are scored along with subjective interpretation by the test administrator.
