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Study to Evaluate Safety and Pharmacokinetics of UB-421 Antibody in HIV-1 Infected Adults

2014-08-27 03:13:03 | BioPortfolio

Summary

The purpose of this Phase I study is to determine whether the antibody (UB-421), targeting the HIV-1 receptor on the CD4 molecule (domain 1) of T-lymphocytes and monocytes, is safe and well tolerated when administered to asymptomatic HIV-1 infected adults by intravenous infusion and to assess pharmacokinetic parameters of the antibody in blood and on cells. The neutralizing activity of UB-421 blocks HIV-1 from binding to its receptor on CD4-positive cells; thus, UB-421 functions as an immunotherapeutic intervention to prevent HIV-1 infection.

Study Design

Control: Uncontrolled, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

HIV-1 Infection in Adults (Asymptomatic)

Intervention

Antibody UB-421

Location

Taipei Veterans General Hospital (TVGH)
Taipei City
Beitou District
Taiwan
11217

Status

Recruiting

Source

United Biomedical

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:03-0400

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