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PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.
- To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML).
- To determine if abnormal expression of Mer and Axl are associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients.
OUTLINE: This is a multicenter study.
Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.
gene expression analysis, western blotting, flow cytometry, laboratory biomarker analysis
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:13:07-0400
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A method that is used to detect DNA-protein interactions. Proteins are separated by electrophoresis and blotted onto a nitrocellulose membrane similar to Western blotting (BLOTTING, WESTERN) but the proteins are identified when they bind labeled DNA PROBES (as with Southern blotting (BLOTTING, SOUTHERN)) instead of antibodies.
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