CPAP, the standard treatment for Obstructive Sleep Apnea Syndrome (OSAS) that reduces sleep fragmentations and neurocognitive deficit in OSAS may also have a key role in reduction of cardiovascular, mortality risks in the same patients.
Obstructive sleep apnea (OSA) is a condition in which there is collapse of the upper airway during sleep, as a result of which there is a decrease or complete cessation of airflow. This leads to repeated episodes of hypoxia during sleep and sleep fragmentation. It is a highly prevalent though under-recognized clinical problem.There is increasing evidence that inflammation plays important role in development of cardiovascular complications in patients with OSA.
Continuous positive airway pressure (CPAP) is the standard treatment for OSA with significant symptoms.However, it is a costly treatment option and poor compliance is an important limiting factor. CPAP treatment has been shown to improve the daytime somnolence and neurocognitive function in people with OSAS. However, its effect on cardiovascular biomarkers in people with OSAS has not been satisfactorily assessed.
This study aims to assess the effect of CPAP treatment on cardiovascular biomarkers in OSA.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Obstructive Sleep Apnea
AutoSet Spirit--Wash--Modified-AutoSet Spirit, Modified-AutoSet Spirit--Wash-AutoSet Spirit
All India Institute of Medical Sciences
New Delhi
Delhi
India
110029
Recruiting
All India Institute of Medical Sciences, New Delhi
Published on BioPortfolio: 2014-07-23T21:08:51-0400
Metabolic syndrome is a constellation of risk factors for cardiovascular disease. The prevalence of metabolic syndrome in persons with obstructive sleep apnea syndrome (OSAS) is known to b...
Two-Phased Study of SPIRIT in Mild AD
The proposed study will adapt and pilot test an efficacious advance care planning interventions, SPIRIT (Sharing Patient's Illness Representations to Increase Trust), with patients with mi...
The goals of this study are to evaluate the effects of an in-home parenting education program, called Family Spirit, on parenting knowledge and skills and decreasing alcohol and substance ...
An Effectiveness-Implementation Trial of SPIRIT in ESRD
Despite advances in dialysis, only 50% of dialysis patients are alive 3 years after the onset of end-stage renal disease (ESRD). Although withdrawal of dialysis precedes 1 in 4 deaths of p...
Evaluation of New Diagnostic and Treatment Algorithm for Obstructive Sleep Apnea
Newer home sleep study device and algorithm provides an alternative for inpatient sleep study and improve the service provides to patients
This study sought to demonstrate causal effects of exposure to Natural American Spirit (NAS) advertising content on misinformed beliefs of current and former smokers, and to empirically establish thes...
Self-consistent parallel imaging (SPIRiT) is an auto-calibrating model for the reconstruction of parallel magnetic resonance imaging, which can be formulated as a regularized SPIRiT problem. The Proje...
Attributes of Iranian new nurse preceptors: A phenomenological study.
Preceptors should possess attributes which help them in successfully performing the demanding and challenging role in the preceptorship. This research utilises a qualitative hermeneutic phenomenologic...
Spirit Possession
The idea that abnormal behavior or a medical condition is evidence that a person is under the control of a supernatural power or spirit. This belief was most commonly held in religion and medicine of the medieval period and is also held in many tribal cultures today.
Food, Genetically Modified
Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).
Morale
The prevailing temper or spirit of an individual or group in relation to the tasks or functions which are expected.
Courage
State of mind or spirit that enables one to act in the face of perceived danger, difficulty, or pain.
Nucleoside Q
A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.