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Dexamethasone Efficacy in HELLP I Syndrome

2014-08-27 03:13:08 | BioPortfolio

Summary

The purpose of this study is to determine the efficacy of dexamethasone for treatment of HELLP I (hemolysis, elevated liver enzymes and low platelet count) syndrome.

Description

Treatment of HELLP syndrome usually is restricted to measures of support and treatment of complications. In 2005, in a subgroup analysis we showed that, among patients with HELLP 1, there were a shorter average time to platelet recovery and less duration of hospitalization in women who received dexamethasone therapy, however the importance of this finding is diminished because this was an unplanned analysis and the severity of the disease was not taken into account at randomization.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

HELLP Syndrome

Intervention

Dexamethasone, sterile water

Location

Universidad del Valle
Cali
Valle
Colombia
57

Status

Recruiting

Source

Universidad del Valle, Colombia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:08-0400

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PubMed Articles [11171 Associated PubMed Articles listed on BioPortfolio]

Case Report of Liver Rupture with Fulminant HELLP Syndrome in the 37th Gestational Week.

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Medical and Biotech [MESH] Definitions

A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.

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A putative protein interaction module, approximately 70 amino acids long, that forms a small five-helix bundle with two large interfaces which may homo- and hetero-oligomerize, or bind non-sterile-alpha motif targets. The sterile alpha motif is present in a wide variety of eukaryotic proteins that function in diverse biological processes.

An anti-inflammatory 9-fluoro-glucocorticoid.

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