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Hematological Clozapine Monitoring With a Point-of-care Device (CHEMPAQ)

2014-08-27 03:13:08 | BioPortfolio

Summary

Clozapine remain the drug of choice for treatment resistant schizophrenia and up to 60% of patients not responding to other antipsychotics will respond to clozapine. However, the use of clozapine is restricted due to the risk of agranulocytosis and consequently the need for mandatory hematological monitoring. CHEMPAQ XBC is a point-of-care device that can be used in patients home and analyze WBC and granulocytes by a single capillary blood drop. This study aims to investigate whether this new procedure increases the acceptability of clozapine

Study Design

Observational Model: Case-Crossover, Time Perspective: Prospective

Conditions

Schizophrenia

Intervention

Venous blod sample, CHEMPAQ

Location

Aalborg Psychiatric Hospital
Aalborg
Denmark
9000

Status

Recruiting

Source

University of Aarhus

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:08-0400

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Medical and Biotech [MESH] Definitions

Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.

The number of PLATELETS per unit volume in a sample of venous BLOOD.

The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.

The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

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