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Tenofovir Renal Toxicity and Glomerular Filtration Rate (GFR) Validation

2014-08-27 03:13:08 | BioPortfolio

Summary

To assess and validate equation eGFR in HIV-infected subjects and -uninfected Thai patients

Description

With significant reductions in mortality and risk of progression to AIDS with antiretroviral therapy (ART), complications of long-standing HIV infection and treatment, including renal disease, have become increasingly important. Aging, concomitant metabolic diseases, and use of potentially nephrotoxic ART lead to higher risk for renal disease in HIV-infected persons.WHO encourage TDF as first line ARV regimen. The data on TDF related renal toxicity in Asian population is limited.

For this cohort, we plan to look at these topics:

1. proximal tubular dysfunction between TDF and non-TDF user

2. incidence and predictor of TDF related renal toxicity

3. TDF plasma concentrations

4. Pharmacokinetic of TDF when used with boosted DRV, boosted ATV, and boosted LPV in Thai population

5. Bone density and vitamin D in patients with and without hypophosphatemia.

6. Pharmacogenomic of TDF in Thai population

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Conditions

Renal Function

Intervention

Tc99mDTPA renal clearance

Location

HIV-NAT, Thai Red Cross AIDS Research Centre
Bangkok
Thailand
10330

Status

Recruiting

Source

The HIV Netherlands Australia Thailand Research Collaboration

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:08-0400

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Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.

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