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This is a Phase 2 study designed to evaluate the safety and efficacy of ABT-384 in approximately 260 adults with mild-to-moderate Alzheimer's Disease (AD). Subjects will be randomized to one of four treatment groups (ABT-384, donepezil, or placebo) for a 12-week Treatment Period.
Acronyms are listed in the secondary outcome section. Below you will find a list of the acronyms defined.
- MMSE - Mini Mental Status Exam
- QoL-AD - Quality of Life - Alzheimer's Disease
- CIBIC-plus - Clinician Interview - Based Impression of Change
- NPI - Neuropsychiatric Inventory
- CSDD - The Cornell Scale for Depression in Dementia
- ADCS-ADL - Alzheimer's Disease Cooperative Study - Activities of Daily Living
Additional oversight authorities are:
- United Kingdom EC: Multicentre Research Ethics Committee (MREC)
- Russia EC: Ethics Committee Under the Federal Service on Surveillance in Healthcare and Social Development of Russian Federation
- Ukraine EC: Central Ethic Commission of Ministry of Health of Ukraine
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
ABT-384, donepezil, placebo
Published on BioPortfolio: 2014-08-27T03:13:09-0400
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