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Probiotics for Reduction Of Markers In Subjects With Allergy

2014-08-27 03:13:10 | BioPortfolio

Summary

In vitro studies reveal immunomodulatory effects of probiotic bacteria that are strain-dependent. Differential immunomodulatory in vitro capacities can not be extrapolated directly to in vivo efficacy. Thus, in vitro screening should be followed by comparative analysis of the selected immunomodulatory probiotic strains in an in vivo setting. Birch pollen allergy is one of the most common forms of respiratory allergy in European countries, and recognized by a Th2-skewed immune system. Five Lactobacillus strains will be evaluated for their immunomodulatory properties in birch pollen sensitive subjects outside the hay fever season. A double-blind placebo-controlled parallel study will be performed in which subjects with a proven birch pollen allergy will consume one of 5 different probiotic yoghurts containing 4 L. plantarum strains and 1 L. casei strain or a placebo yoghurt. Blood samples are collected at the start and after 4 weeks. Immune parameters are determined in serum and peripheral blood mononuclear cell cultures (hPBMC) derived from these subjects.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Hay Fever

Intervention

Yoghurt with L. plantarum strain, Yoghurt with L.casei, Yoghurt with L. plantarum strain, Yoghurt with L. plantarum strain, Yoghurt with L. plantarum strain, Yoghurt

Location

Allergologiepraktijk Arnhem/Radboud/Rijnstate
Arnhem
Gelderland
Netherlands
6824 BJ

Status

Completed

Source

Rijnstate Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:10-0400

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