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Autonomic Nervous System and Nitric Oxide Interactions

2014-07-10 14:06:06 | BioPortfolio

Summary

The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function. In particular, the investigators will study how endothelial function changes during autonomic withdrawal.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)

Conditions

Endothelial Dysfunction

Intervention

Trimethaphan, Placebo

Location

Vanderbilt University Medical Center
Nashville
Tennessee
United States
37232

Status

Active, not recruiting

Source

Vanderbilt University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-10T14:06:06-0400

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Medical and Biotech [MESH] Definitions

A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.

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Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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