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Aromatase (CYP19) Polymorphism Between AI-responsive and AI-resistant Breast Cancer in Korea

2014-08-27 03:13:10 | BioPortfolio

Summary

Aromatase(CYP19)inhibitor is one of the major antihormonal drug for breast cancer in postmenopausal women. The variation of CYP19 may affect the effect of aromatase inhibitor. However, the incidence of variation of CYP19 in Korea has not known. Therefore, the investigators want to know the incidence of variation of CYP19 and to assess the effect of these variations of CYP19 to aromatase inhibitor users.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Polymorphism

Location

Samsung Medical Center
Seoul
Korea, Republic of
135-710

Status

Active, not recruiting

Source

Samsung Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:10-0400

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Medical and Biotech [MESH] Definitions

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.

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A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

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Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.

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