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Non Surgical Management for Uterine Residua After Pregnancy Termination, Abortion or Delivery

2014-08-27 03:13:15 | BioPortfolio

Summary

The aim of the study is to find out whether conservative treatment - expectant management or medical therapy using misoprostol is beneficial in the case of uterine residua, and which treatment is better.

Description

Retained products of conception are estimated to occur after approximately 1-6% of pregnancies, probably more often after termination of early pregnancies then after term pregnancy. Complication are abdominal pain, infection, bleeding and for the long term - intrauterine adhesions.Blood clots in the uterine cavity can cause similar complications. The definitive treatment is curettage or hysteroscopy, both of which are carried out under general anesthesia and require an operating theater. Although expectant management and uterotonic drugs are practically used in such situation, they are not described in the literature.This study compare between the outcome of misoprostol treatment and expectant management in the case of intrauterine residua after completion of pregnancy.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Intra-uterine Residua

Intervention

misoprostol

Location

HaEmek medical center
Afula
Israel

Status

Not yet recruiting

Source

HaEmek Medical Center, Israel

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:15-0400

Clinical Trials [873 Associated Clinical Trials listed on BioPortfolio]

Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion

This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol

Misoprostol Prior to Intra-Uterine Device (IUD) Insertion in Nulliparous Women

The purpose of this study is to see if inserting misoprostol in the vagina or between your cheek and gum before inserting an IUD in a woman who has never had a baby makes it easier and les...

Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions

Patients suffering of subfertility as a consequence of intra uterine adhesions could be treated with adhesiolysis by hysteroscopy. Post-operative recurrent adhesions could be developed. To...

the Effect of Misoprostol on Intra-operative Blood Loss During Myomectomy Operation : RCT

assess the effect of using misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications. Research question Does pre-operativ...

Diffusion-weighted Cerebral MRI and Intra Uterine Growth Restriction.

The purpose of this study is to compare the apparent diffusion coefficient in the frontal lobe of foetuses with intra-uterine growth restriction and poor neonatal outcome compared with foe...

PubMed Articles [1996 Associated PubMed Articles listed on BioPortfolio]

Rectal vs. sublingual misoprostol before cesarean section: double-blind, three-arm, randomized clinical trial.

The commonest surgical procedure for women is cesarean delivery. Postpartum hemorrhage and intra-operative blood during cesarean delivery is a major concern to all obstetricians. This study was conduc...

Mifepristone Pretreatment for the Medical Management of Early Pregnancy Loss.

Medical management of early pregnancy loss is an alternative to uterine aspiration, but standard medical treatment with misoprostol commonly results in treatment failure. We compared the efficacy and ...

Efficacy and safety of misoprostol vaginal insert vs. oral misoprostol for induction of labor.

Is There a Benefit to Culturing Intra-Uterine Devices in Pelvic Inflammatory Disease?

The study aimed to compare the clinical course and disease severity between culture positive and culture negative patients with intra-uterine devices (IUD)-associated pelvic inflammatory disease (PID)...

Pharmacokinetics and ex vivo anti-inflammatory effects of oral misoprostol in horses.

Misoprostol is an E prostanoid (EP) 2, 3, and 4 receptor agonist that is anecdotally used to treat and prevent NSAID-induced GI injury in horses. Misoprostol elicits anti-inflammatory effects in vivo ...

Medical and Biotech [MESH] Definitions

Inflation of a balloon catheter within the uterine cavity to control UTERINE HEMORRHAGE.

Measurement or recording of contraction activity of the uterine muscle. It is used to determine progress of LABOR, OBSTETRIC and assess status of pregnancy. It is also used in conjunction with FETAL MONITORING to determine fetal response to stress of maternal uterine contractions.

Pathological processes of the UTERINE CERVIX.

Tumors or cancer of the UTERINE CERVIX.

Loss or destruction of the epithelial lining of the UTERINE CERVIX.

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