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Non Surgical Management for Uterine Residua After Pregnancy Termination, Abortion or Delivery

2014-08-27 03:13:15 | BioPortfolio

Summary

The aim of the study is to find out whether conservative treatment - expectant management or medical therapy using misoprostol is beneficial in the case of uterine residua, and which treatment is better.

Description

Retained products of conception are estimated to occur after approximately 1-6% of pregnancies, probably more often after termination of early pregnancies then after term pregnancy. Complication are abdominal pain, infection, bleeding and for the long term - intrauterine adhesions.Blood clots in the uterine cavity can cause similar complications. The definitive treatment is curettage or hysteroscopy, both of which are carried out under general anesthesia and require an operating theater. Although expectant management and uterotonic drugs are practically used in such situation, they are not described in the literature.This study compare between the outcome of misoprostol treatment and expectant management in the case of intrauterine residua after completion of pregnancy.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Intra-uterine Residua

Intervention

misoprostol

Location

HaEmek medical center
Afula
Israel

Status

Not yet recruiting

Source

HaEmek Medical Center, Israel

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:15-0400

Clinical Trials [769 Associated Clinical Trials listed on BioPortfolio]

Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion

This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol

Misoprostol Prior to Intra-Uterine Device (IUD) Insertion in Nulliparous Women

The purpose of this study is to see if inserting misoprostol in the vagina or between your cheek and gum before inserting an IUD in a woman who has never had a baby makes it easier and les...

Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions

Patients suffering of subfertility as a consequence of intra uterine adhesions could be treated with adhesiolysis by hysteroscopy. Post-operative recurrent adhesions could be developed. To...

the Effect of Misoprostol on Intra-operative Blood Loss During Myomectomy Operation : RCT

assess the effect of using misoprostol in abdominal myomectomy operations on blood loss, duration of the operation and possible operative complications. Research question Does pre-operativ...

Diffusion-weighted Cerebral MRI and Intra Uterine Growth Restriction.

The purpose of this study is to compare the apparent diffusion coefficient in the frontal lobe of foetuses with intra-uterine growth restriction and poor neonatal outcome compared with foe...

PubMed Articles [1988 Associated PubMed Articles listed on BioPortfolio]

Uterine balloon tamponade as an adjunct to misoprostol for the treatment of uncontrolled postpartum haemorrhage: a randomised controlled trial in Benin and Mali.

To assess the effectiveness of low-cost uterine tamponade as an adjunct to misoprostol for the treatment of uncontrolled postpartum haemorrhage (PPH) in low-resource settings.

Expectant management and laser photocoagulation in isolated Selective Intra-Uterine Growth Restriction: a single-center series.

The objective was to report on a consecutive series of monochorionic diamniotic pregnancies complicated by selective Intra-Uterine Growth Restriction (sIUGR) and to describe perinatal outcomes based o...

Induction of Labor Using One Dose versus Multiple Doses of Misoprostol - A Randomized Controlled Trial.

Misoprostol is a common agent used to ripen the cervix and induce labor, yet there is no clear evidence of the optimal number of doses needed to achieve a higher rate of vaginal delivery.

Operative technique at caesarean delivery and risk of complete uterine rupture in a subsequent trial of labour at term. A registry case-control study.

To estimate the relation of single-layer closure at previous caesarean delivery, and other pre-labour and intra-partum risk factors for complete uterine rupture in trial of vaginal birth after a caesa...

Molecular signature and functional analysis of uterine ILCs in mouse pregnancy.

In addition to natural killer cells, other innate lymphoid cells have recently been identified in the mouse and human uterus, but their roles in successful pregnancy remain poorly defined. In this stu...

Medical and Biotech [MESH] Definitions

Inflation of a balloon catheter within the uterine cavity to control UTERINE HEMORRHAGE.

Measurement or recording of contraction activity of the uterine muscle. It is used to determine progress of LABOR, OBSTETRIC and assess status of pregnancy. It is also used in conjunction with FETAL MONITORING to determine fetal response to stress of maternal uterine contractions.

Pathological processes of the UTERINE CERVIX.

Tumors or cancer of the UTERINE CERVIX.

Loss or destruction of the epithelial lining of the UTERINE CERVIX.

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