Track topics on Twitter Track topics that are important to you
- The purpose of the 1982-1986 North Carolina Early Pregnancy Study was to determine how often pregnancy loss occurs before women know they are pregnant. Women planning to become pregnant were asked to collect daily urine specimens and fill out daily diaries of their intercourse and menstrual bleeding. Researchers are interested in re-contacting this cohort to gather new information and to examine how accurately women can recall events that occurred earlier in their lives.
- To follow-up with and gather additional information from women who were involved in the Early Pregnancy Study.
- Women who participated in the 1982-1986 North Carolina Early Pregnancy Study.
- Participants will receive and complete a questionnaire that includes the following topics:
- Their pregnancy history.
- The infant's birth, including method of delivery and induction of labor.
- Early life exposures such as their own birth weight and their parents' ages at their birth.
- Tap water use during their attempt to conceive
- General description of their behaviors during their participation in the original study, these include: physical activity, caffeine, alcohol, and soy food consumption.
- Participants will return the surveys to the researchers in the stamped envelope provided with the questionnaire....
We propose a follow-up study of women who participated in the North Carolina Early Pregnancy Study (EPS) in 1982-1986. Women enrolled in the study after discontinuing birth control and were followed for the occurrence of a pregnancy. Participants completed daily diaries and collected first morning urine specimens which allowed the identification of menstrual cycles. Thus each woman's time to pregnancy was prospectively measured. We intend to trace the women and ask them to complete a questionnaire that includes their recall of their time to pregnancy during the study. This will allow us to address two major questions, one regarding the recall of time-to-pregnancy, and the other regarding the natural length of gestation.
1. Recall of time-to-pregnancy
Time to pregnancy is a commonly studied estimate of fecundability. This outcome has been used to study the reproductive effects of environmental toxins, cigarette smoking, obesity and numerous other exposures. Prospective studies of time to pregnancy require enrollment of women who are just starting to attempt pregnancy and following them until a pregnancy is conceived. This type of study can be time-consuming and costly. It is also difficult to identify a population of women who are just beginning to attempt pregnancy. A more efficient design is to ask women to recall their time to pregnancy. This design is limited however, as it is unknown how well women can recall their time to pregnancy. Only two studies have examined this question in a population with both prospective and retrospectively recalled time to pregnancy. One of the studies involved women from the Netherlands, the recall period was short (3-20 months), and only part of the woman's time to pregnancy was prospectively observed. The second study had a longer recall period (1-10 years) but included only 43 women.
2. Length of gestation
Gestational length is the time from conception to delivery. The EPS has very good data on the first data point, and we know date of delivery. However, our data on delivery is limited by the fact that we do not know which deliveries were induced and which were the product of natural onset of labor and delivery. We plan to collect this information from the mothers. Such information will not only allow us to consider the natural variability in gestational age (a measure that does not exist at present) but also to estimate associations between events in very early pregnancy and the subsequent duration of pregnancy. The EPS has detailed measurements of the time from ovulation to implantation, the rate of increase in human chorionic gonadotropin and corpus luteum rescue. To our knowledge, these early pregnancy characteristics have not been investigated for associations with length of gestation.
Time Perspective: Retrospective
NIEHS, Research Triangle Park
Research Triangle Park
National Institutes of Health Clinical Center (CC)
Published on BioPortfolio: 2014-08-27T03:13:21-0400
The broad, long-term objectives are to generate and test hypotheses leading to theories that guide improved care of patients with gestational diabetes. The purpose of this chart review st...
Retrospective study to estimate screening of the type 2 diabetes of women who had childbirth in the Hospital center Rene Dubos and having gestational diabetes.
This study evaluated the periodontal condition of gestational diabetes mellitus (GDM) patients and a healthy non-pregnant control group. For the GDM group all medical data were recorded, i...
The aim of this pilot study is to conduct a dietary intervention for overweight (body maas index BMI≥25) and obese (BMI≥30) pregnant women in two maternity care clinics and explore the...
The purpose of this study is to document the gut microbiome in the 1st, 2nd and 3rd trimester among pregnant women with gestational diabetes and non diabetic controls.
Comparison of diurnal variations, gestational age and gender related differences in fetal heart rate (FHR) parameters between appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) fetuses in the home environment.
To assess the influence of gender, time of the day and gestational age on fetal heart rate (FHR) parameters between appropriate-for-gestational-age (AGA) and small-for-gestational age (SGA) fetuses us...
To compare fetal heart rate (FHR) patterns during the last hour of labor between small-for-gestational-age (SGA; birth weight less than the 10th percentile for gestational age) and appropriate-for-ges...
Both obesity and gestational diabetes (GDM) are risk factors for adverse pregnancy outcomes. The aim of our study is to ascertain the independent role of prepregnancy BMI (pp-BMI), gestational weight ...
Antibiotics are commonly used in pregnancy. Prior studies have indicated that antibiotic use in pregnancy may affect birth weight, whereas data in nonpregnant individuals suggest that antibiotic ex...
To (i) evaluate the global impact of interventions designed to prevent excessive gestational weight gain (eGWG) on the incidence of gestational diabetes (GDM), and (ii) examine whether the effects dif...
Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)
An infant having a birth weight lower than expected for its gestational age.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Round-shaped structure usually located in the upper fundus of the UTERUS in early pregnancy. It comprises EMBRYO; AMNIOTIC FLUID; and YOLK SAC. It is visible in PRENATAL ULTRASONOGRAPHY by the fifth week of pregnancy. Its size is often used to determine and monitor GESTATIONAL AGE; FETAL GROWTH; and PREGNANCY COMPLICATIONS.
A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.
Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...