Genetic Basis for Heterogeneity in Response of Plasma Lipids to Plant Sterols
Summary
The present study's goal is to identify a genetic basis for variations in responsiveness to plant sterol use, and elucidate which components of control of cholesterol metabolism associate with the genetic factors identified. The long term target is to contribute to a growing database that will be used in conjunction with rapid genotyping assays to allow future practitioners to determine if plant sterol intervention will be an effective lipid-lowering therapy in at-risk patients. Specifically, it is hypothesized that haplotype frequencies for key lipid regulatory genes will associate with (i) plasma lipid and non cholesterol sterol (lathosterol and sitosterol) profiles, (ii) whole-body cholesterol absorption and synthesis and iii) the expression of cholesterol responsive genes in response to plant sterol consumption.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Conditions
Hyperlipidemia
Intervention
Plant sterol, Placebo
Location
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
Winnipeg
Manitoba
Canada
R3T 6C5
Status
Recruiting
Source
University of Manitoba
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01131832
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:13:22-0400
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Medical and Biotech [MESH] Definitions
Sterol Regulatory Element Binding Proteins
Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Oxysterols
Oxygenated derivatives of cholesterol or its sterol precursors. They are generated from sterol metabolism and the interaction of cholesterol with REACTIVE OXYGEN SPECIES.
Sterol 14-demethylase
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Sterol Esterase
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
Sterol Regulatory Element Binding Protein 2
A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.
