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The present study's goal is to identify a genetic basis for variations in responsiveness to plant sterol use, and elucidate which components of control of cholesterol metabolism associate with the genetic factors identified. The long term target is to contribute to a growing database that will be used in conjunction with rapid genotyping assays to allow future practitioners to determine if plant sterol intervention will be an effective lipid-lowering therapy in at-risk patients. Specifically, it is hypothesized that haplotype frequencies for key lipid regulatory genes will associate with (i) plasma lipid and non cholesterol sterol (lathosterol and sitosterol) profiles, (ii) whole-body cholesterol absorption and synthesis and iii) the expression of cholesterol responsive genes in response to plant sterol consumption.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Plant sterol, Placebo
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba
University of Manitoba
Published on BioPortfolio: 2014-08-27T03:13:22-0400
The purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.
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The study is a randomised, double-blind, placebocontrolled, parallel dose-response study with four study arms. Sixty subjects will be randomly allocated to consume study products containin...
This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheroma...
This randomized controlled double-blind intervention study unravels influence of dietary plant sterols and stanols on the structure and the sterol composition of the human aortic valve. Th...
The meta-analysis of plant sterol supplement studies suggests an 8% lowering of low density lipoprotein (LDL) cholesterol for 2 to 2.5 g/day of plant sterols. Cereal foods have been rarely tested, and...
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Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Oxygenated derivatives of cholesterol or its sterol precursors. They are generated from sterol metabolism and the interaction of cholesterol with REACTIVE OXYGEN SPECIES.
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma. It is an important structural component of mammalian cell membranes, where it is establishes proper membrane permeability and fluidity. Cholesterol ...
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...