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To compare the complete healing of erosive esophagitis(EE) after 3 weeks of treatment with Secretol 60 mg versus Nexium 40 mg daily.
We hypothesize that Secretol 60 mg daily will demonstrate better efficacy than Nexium 40 mg daily in healing EE and controlling GERD-related symptoms after 3 weeks of treatment.In addition, Secretol 60 mg daily will have a faster effect on the aforementioned clinical parameters but a similar safety profile.
Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Southern Arizona Veterans Health Care System
Southern Arizona VA Health Care System
Published on BioPortfolio: 2014-07-23T21:08:59-0400
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Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.
Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.
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A substituted benzamide used for its prokinetic properties. It is used in the management of gastroesophageal reflux disease, functional dyspepsia, and other disorders associated with impaired gastrointestinal motility. (Martindale The Extra Pharmacopoeia, 31st ed)
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