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Short-course Preoperative Chemoradiotherapy Followed by Delayed Operation for Locally Advanced Rectal Cancer

2014-08-27 03:13:27 | BioPortfolio

Summary

Concurrent chemoradiotherapy (CRT)

- Radiotherapy 25 ㏉/5 fractions (start concomitantly at D1)

- ↓ ↓ ↓ ↓ ↓

- Radical surgery 6 weeks after completion of chemoradiotherapy

- ↑ ↑ ↑ ↑ ↑ D1 - - - - - D5

- 5-Fluorouracil 400㎎/㎡/day + LV 20㎎/㎡/day IV bolus during the radiotherapy

Description

Radiotherapy using tomotherapy is delivered in 5 Gy daily fractions for a total of 25 Gy in 5 fractions.

A bolus injection of 5-fluorouracil (400 mg/m2/d)and leucovorin (20 mg/m2/d) is delivered concurrently on day 1-5 during radiotherapy.

Total mesorectal excision is performed within 6±2 weeks. The pathological response of downstaing is the study endpoint.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Rectal Cancer

Intervention

Radiation: short-course preoperative chemoradiotherapy

Location

National Cancer Center Korea
Goyang-si
Gyeonggi-do
Korea, Republic of
410-769

Status

Completed

Source

National Cancer Center, Korea

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:27-0400

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