The Effect of a Non-hormonal Cox-2 Inhibitor (Celebrex) on Ovulation

2014-08-27 03:13:27 | BioPortfolio


The purpose of this study is to assess the effect that Celebrex (a COX-2 inhibitor and non-steroidal anti-inflammatory drug {NSAID}) has on ovulation.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Diagnostic






Oregon Health & Science University
United States




Oregon Health and Science University

Results (where available)

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Published on BioPortfolio: 2014-08-27T03:13:27-0400

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The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle

The investigators propose to test the hypothesis that the use of a prostaglandin inhibitor will result in premature luteolysis (ovulation failure) in women.

Celebrex and Metformin for Postoperative Hepatocellular Carcinoma

This prospective trial aims to compare the role of celebrex alone, metformin alone, and celebrex plus metformin in preventing HCC recurrence after hepatic resection.

The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure. There have been many studies done with analgesics ...

Celebrex Premedication in Teeth With Symptomatic Irreversible Pulpitis

Assessing the efficacy of Celebrex premedication on pain during and after endodontic treatment in teeth with symptomatic irreversible pulpits

Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.

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PubMed Articles [106 Associated PubMed Articles listed on BioPortfolio]

Igf3 serves as a mediator of LH in zebrafish ovulation.

Both oocyte maturation and ovulation is triggered by the luteinizing hormone (LH) surge in vertebrates, but exactly how these processes are regulated by LH remains to be fully elucidated. Previously w...

Candidate gene identification of ovulation-inducing genes by RNA sequencing with an in vivo assay in zebrafish.

We previously reported the microarray-based selection of three ovulation-related genes in zebrafish. We used a different selection method in this study, RNA sequencing analysis. An additional eight up...

Effect of copulation on estrus duration, LH response, and ovulation in Boer goats.

The objectives of this investigation were to determine the effect of copulation on estrus duration, LH response and ovulation in Boer goats. A controlled randomized study, with two replicates, in whic...

Co-ordination of ovulation and oocyte maturation: A good egg at the right time.

Ovulation is the appropriately timed release of a mature developmentally competent oocyte from the ovary into the oviduct where fertilization occurs. Importantly, ovulation is tightly linked with oocy...

Ovulation induction strategies in polycystic ovary syndrome.

We thank Levin and Rottenstreich for their interest in our article on ovulation induction strategies in polycystic ovary syndrome (PCOS). We suggested as a second line treatment after life style chang...

Medical and Biotech [MESH] Definitions

Blocking the process leading to OVULATION. Various factors are known to inhibit ovulation, such as neuroendocrine, psychological, and pharmacological agents.

The period in the MENSTRUAL CYCLE that is optimal for FERTILIZATION of the OVUM and yielding PREGNANCY. The duration of fertile period depends on the life span of male GAMETES within the female reproductive tract and the time of OVULATION. It usually begins a few days before ovulation and ends on the day of ovulation.

Predicting the time of OVULATION can be achieved by measuring the preovulatory elevation of ESTRADIOL; LUTEINIZING HORMONE or other hormones in BLOOD or URINE. Accuracy of ovulation prediction depends on the completeness of the hormone profiles, and the ability to determine the preovulatory LH peak.

Method to determine the occurrence of OVULATION by direct or indirect means. Indirect methods examine the effects of PROGESTERONE on cervical mucus (CERVIX MUCUS), or basal body temperature. Direct ovulation detection, generally used in fertility treatment, involves analyses of circulating hormones in blood and ULTRASONOGRAPHY.

Techniques for the artifical induction of ovulation, the rupture of the follicle and release of the ovum.

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