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The Effect of High PCO2 Solution on Esophageal Acid Sensation

2014-07-23 21:09:00 | BioPortfolio

Summary

To determine the effect of intraesophageal high PCO2 solution as compared to acidic and saline solutions on subjects' heartburn sensation using stiumlus-response functions.

Description

Presently, the exact mechanism of GERD and the role of CO2 in pathogenesis of heartburn symptoms is unclear. CO2 conversion to protons may play a key role in the mechanism for heartburn sensation. This is a prospective, randomized study that will help further explore the mechanism for heartburn sensation in GERD patients and can be a prelude for further studies examining the role of new class antireflux agents such as carbonic anhydrase inhibitors in the treatment of patients with heartburn.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Gastroesophageal Reflux Disease

Location

Southern Arizona VA Health Care System
Tucson
Arizona
United States
85723

Status

Recruiting

Source

Southern Arizona VA Health Care System

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:00-0400

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