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Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy

2014-08-27 03:13:28 | BioPortfolio

Summary

Certain kind of neurosurgical procedures require intraoperative alertness of the patient, for example to perform speech tests during brain tumor resection. With respect to anaesthesia, it is therefore required that the patient is asleep during the beginning and the end of the procedure, however fully awake in between. To do so, the anaesthetic propofol is used and an accurate knowledge of its pharmacokinetic and -dynamic (pk/pd) parameters is required to optimally control anaesthesia. However, diverse pk/pd-parameter sets have been described in the literature.

The aim of the study is to investigate whether the pk/pd model proposed by Marsh et al. or by Schnider et al. more accurately describe the pk/pd of propofol during awake craniotomy.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Brain Tumor

Location

Dept. of Anaesthesiology and Intensive Care Medicine, Univ. of Bonn
Bonn
Germany
53105

Status

Recruiting

Source

University Hospital, Bonn

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:28-0400

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Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

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