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Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women

2014-08-27 03:13:34 | BioPortfolio

Summary

This protocol is a controlled study of estradiol therapy in early postmenopausal women with and without frequent hot flashes that will be used to determine whether hot flashes are an important intermediary in the generation of menopause-associated depression

SPECIFIC AIMS (Research Objectives) To define the relative effects of hot flashes and changes in estradiol on mood in postmenopausal women

Hypotheses:

1. Estrogen treatment has a similar therapeutic effect on mood in women with and without frequent hot flashes

2. Estradiol levels correlate with improvement in mood

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Menopausal Depression

Intervention

Estradiol, Placebo control

Location

Massachusetts General Hospital
Boston
Massachusetts
United States
02114

Status

Recruiting

Source

Massachusetts General Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:34-0400

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