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Immunoadsorption in Patients With Pulmonary Hypertension

2014-08-27 03:13:34 | BioPortfolio

Summary

The purpose of this study is to investigate, if Immunoadsorption of autoantibodies with subsequent substitution of immunoglobulins is able to improve haemodynamics in patients with pulmonary hypertension.

Description

Increased pulmonary precapillary vascular resistance due to vasoconstriction and vasoproliferative processes is the basic pathophysiological mechanism in the development of pulmonary hypertension (PH). In patients with pulmonary arterial hypertension (PH) production of endothelin-1 (ET-1) is increased and elevated ET-1 plasma levels correlate with PH severity As recently shown Autoantibodies against the Endothelin-1 Typ A and Angiotensin II Typ-1 Receptor, which have a high Incidence in PH-Patients, may also play an important role in the pathophysiology of PH (Dandel et al.).

The concept of this study is that the elimination of these autoantibodies by Immunoadsorption with protein A may improve haemodynamics and patient wellbeing. Immunoglobulins are substituted after Immunoadsorption to minimize infection risk.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Pulmonary Hypertension

Intervention

immunoadsorption / immunglobulin substitution

Location

Ernst Moritz Arndt Universität Greifswald
Greifswald
MV
Germany
17489

Status

Recruiting

Source

Ernst Moritz Arndt University of Greifswald

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:34-0400

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Medical and Biotech [MESH] Definitions

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