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Cell Culture of Glioma Specimens for in Vitro Preclinical Studies

2014-08-27 03:13:35 | BioPortfolio

Summary

The purpose of this study is to culture primary human brain tumor cells with the specific aims of:

1. Develop primary cultures from human brain tumor surgical specimens

2. Determine the genetic and molecular fingerprints of brain tumors that may have prognostic significance

3. Delineate the mechanisms underlying oncogenesis of brain tumors.

4. Perform in vitro assays with brain tumor derived primary cultures to assess the efficacy of novel therapeutic agents.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Brain Tumor

Location

Albany Medical Center
Albany
New York
United States
12208

Status

Recruiting

Source

Albany Medical College

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:35-0400

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Medical and Biotech [MESH] Definitions

Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

Multi-channel hearing devices typically used for patients who have tumors on the COCHLEAR NERVE and are unable to benefit from COCHLEAR IMPLANTS after tumor surgery that severs the cochlear nerve. The device electrically stimulates the nerves of cochlea nucleus in the BRAIN STEM rather than the inner ear as in cochlear implants.

Bleeding within the brain as a result of penetrating and nonpenetrating CRANIOCEREBRAL TRAUMA. Traumatically induced hemorrhages may occur in any area of the brain, including the CEREBRUM; BRAIN STEM (see BRAIN STEM HEMORRHAGE, TRAUMATIC); and CEREBELLUM.

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