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Study of Fibromyalgia Treated With Milnacipran

2014-08-27 03:13:39 | BioPortfolio

Summary

The purpose of this study is to examine the characteristics of the nerves and the small veins in the skin of people with fibromyalgia. This information will then be used to identify possible processes in the skin that may help explain why some people feel pain relief with the study drug (milnacipran) and others do not. The investigators expect to learn more about the pathophysiology of fibromyalgia and the way in which milnacipran acts on these patients. The investigators hypotheses are:

1. The pathophysiologic basis of fibromyalgia in some patients may be due to a biochemical and/or morphological pathology among the sensory innervation.

2. Fibromyalgia patients may have different sites of innervation.

3. Milnacipran may have a therapeutic effect on some fibromyalgia patients.

4. Abnormalities in fibromyalgia patients may predict the likelihood of a good response to milnacipran.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Fibromyalgia

Intervention

Milnacipran, Skin biopsy

Location

Upstate Clinical Research, LLC
Albany
New York
United States
12205

Status

Recruiting

Source

Albany Medical College

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:39-0400

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Medical and Biotech [MESH] Definitions

A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)

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