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To Study the Effect of Vitamin E and Vitamin C on Restless Leg Syndrome in Hemodialysis Patients

2014-08-27 03:13:39 | BioPortfolio

Summary

Oxidative stress has a role in uremic neuropathy and may be involved in RLS of ESRD patients.Vitamin E &Vitamin C are potential antioxidant supplement that are used in hemodialysis patients safely.

Description

After initial screening according to the International Restless Legs Syndrome Study Group (IRLSSG)criteria, sixty patients fulfilled criteria.Patients were randomly assigned to four therapeutic groups as follows:

Group 1 (n=15): patients received one Tablet of vitamin C (200 mg) plus one capsule placebo for 8 weeks.

Group 2 (n=15): patients received one capsule of vitamin E ( 400 mg ) plus placebo for 8 weeks.

Group 3 (n=15) : patients received one capsule of vitamin E (400 mg) plus one Tablet vitamin C (200 mg) for 8 weeks.

Group 4: patients received two capsule of placebo for 8 weeks. IRLS sum score decreased progressively and significantly in all three groups receiving vitamins compared pre and post treatment with placebo group.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Kidney Disease

Intervention

Vitamin C, Vitamin E, Vitamin C and Vitamin E, Placebo

Location

Shiraz University of Medical Science
Ostan of Fars
Fars
Iran, Islamic Republic of

Status

Completed

Source

Shiraz University of Medical Sciences

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:39-0400

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