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After initial screening according to the International Restless Legs Syndrome Study Group (IRLSSG)criteria, sixty patients fulfilled criteria.Patients were randomly assigned to four therapeutic groups as follows:
Group 1 (n=15): patients received one Tablet of vitamin C (200 mg) plus one capsule placebo for 8 weeks.
Group 2 (n=15): patients received one capsule of vitamin E ( 400 mg ) plus placebo for 8 weeks.
Group 3 (n=15) : patients received one capsule of vitamin E (400 mg) plus one Tablet vitamin C (200 mg) for 8 weeks.
Group 4: patients received two capsule of placebo for 8 weeks. IRLS sum score decreased progressively and significantly in all three groups receiving vitamins compared pre and post treatment with placebo group.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Vitamin C, Vitamin E, Vitamin C and Vitamin E, Placebo
Shiraz University of Medical Science
Ostan of Fars
Iran, Islamic Republic of
Shiraz University of Medical Sciences
Published on BioPortfolio: 2014-08-27T03:13:39-0400
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A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
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