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Safety Study of Two Repeat Doses of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

2014-08-27 03:13:40 | BioPortfolio

Summary

RT001 is safe and well-tolerated following two (2) sequential applications.

Description

Revance is conducting this Phase 2 clinical study to establish the safety of two (2) sequential doses of RT001 Topical Gel at Baseline (Day 0) and Week 4 for the treatment of moderate to severe LCLs at rest.

Study Design

Control: Uncontrolled, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Lateral Canthal Lines

Intervention

RT001

Location

Total Skin & Beauty Dermatology Center, PC
Birmingham
Alabama
United States
35205

Status

Active, not recruiting

Source

Revance Therapeutics, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:13:40-0400

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A 4-Arm Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

The purpose of this study is to find out if an investigational drug, called RT001 Topical Gel, is safe and useful in minimizing the wrinkles between the eye and hairline called lateral can...

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Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

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Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

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Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

The purpose of this study is to determine the safety and efficacy of 2 sequential doses of RT001 compared to vehicle control following applications at Baseline (Day 0) and Week 2.

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Medical and Biotech [MESH] Definitions

Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.

A narrow strip of cell groups on the dorsomedial surface of the thalamus. It includes the lateral dorsal nucleus, lateral posterior nucleus, and the PULVINAR.

This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)

There are two lateral ligaments of the ankle - internal and external. The internal lateral ligament is attached to the apex and anterior and posterior bodies of the inner malleolus and inserted into the navicular bone, the inferior calcaneo-navicular ligament, the sustentaculum tali of the os calcis, and the inner side of the astragalus. The external lateral ligament, also called the lateral collateral ligament, consists of three distinct fasciculi - the calcaneofibular, the anterior talofibular, and the posterior talofibular.

Formation or presence of a blood clot (THROMBUS) in the LATERAL SINUSES. This condition is often associated with ear infections (OTITIS MEDIA or MASTOIDITIS) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; NEUROSURGICAL PROCEDURES; THROMBOPHILIA; and other conditions. Clinical features include HEADACHE; VERTIGO; and increased intracranial pressure.

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