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Evaluation of 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Cancer.

2014-07-24 14:05:44 | BioPortfolio

Summary

This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error verification.Also,the various dosimetric variations in Adaptive RT will be studied.

Description

Aims and Objectives

1. To assess the patient's radiation dose planning for GTV, CTV and PTV for primary and nodal regions and derive comparison between IGRT and 3D-CRT.

2. To assess the dosimetric variation in different phases of adaptive RT due to changes in tumor shape and volume during the course of entire treatment in IGRT arm in head and neck cancer patients.

3. To evaluate the optimal setup correction methodology using planar (EPID) and volumetric images (CBCT) in HNSCC between 3D-CRT and IGRT treatment delivery respectively.

4. To compare the early tumour response and acute and chronic radiation morbidities between IGRT and 3D-CRT.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Head and Neck Cancer

Intervention

EPID Verification, CBCT verification

Location

All India Institute of Medical Sciences
New Delhi
India
110029

Status

Recruiting

Source

All India Institute of Medical Sciences, New Delhi

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:05:44-0400

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